Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABAB receptor

Jang, Eun Young; Choe, Eun Sang; Hwang, Meeyul; Kim, Sang Chan; Lee, Jong Rok; Kim, Sang Geon; Jeon, Jae‐Pil; Buono, Russell J.; Yang, Chae Ha

doi:10.1016/j.ejphar.2008.03.054

Cited by 40 publications

(51 citation statements)

References 30 publications

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“…In a previous study we demonstrated MEGR suppresses cocaine-induced extracellular dopamine release in rat Nacc [12], in the present study …”

Section: ⅳ Discussionmentioning

confidence: 66%

“…Historically, most experimental studies on pharmacological values of G. radix were devoted to its anti-inflammatory and anti-oxidative properties [9,10] neuroprotective effects of G. radix and its bioactive ingredients against various noxious stimuli [11]. Most notably, studies done in our lab have shown that methanol extracts of G. radix (MEGR) and isoliquiritigenin suppress cocaine-induced extracellular dopamine release in rat Nacc through GABAb receptors [12], and isoliquiritigenin also prevents Meth-induced neurotoxicity in mouse brain by inhibiting NF-kB activation [13]. These After MEGR (or vehicle) administration, each rat was allowed to adapt the locomotor testing box for 60 min followed by Meth administration, Watson [14] to obtain Nacc tissues (Fig.…”

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confidence: 99%

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Methanol extract from radix of Glycyrrhizae uralensis attenuate methamphetamine-induced hyperlocomotor activity

Zhao¹,

Wang²,

Lin³

et al. 2014

Herbal Formula Science

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Background and objective: Methamphetamine (Meth) is a widely abused psychostimulant that produces hyperlocomotion in rodents. Radix of Glycyrrhizae uralensis comprises a variety of bioactive components that have neuroprotective effects. In a previous study, we have demonstrated methanol extracts from radix of Glycyrrhizae uralensis (MEGR) suppress acute cocaine-induced extracellular dopamine release in the nucleus accumbens. In the present study, we investigated the effect of MEGR on acute Meth-induced hyperlocomotion.Methods: Male Sprague-Dawley rats were orally administered with MEGR (60 mg/kg and 180 mg/kg) 60 min prior to an intraperitoneal injection of Meth (1.0 mg/kg).Results: Behavioral analysis showed acute Meth greatly increased locomotor activities, while pretreatment

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“…In a previous study we demonstrated MEGR suppresses cocaine-induced extracellular dopamine release in rat Nacc [12], in the present study …”

Section: ⅳ Discussionmentioning

confidence: 66%

mentioning

confidence: 99%

Methanol extract from radix of Glycyrrhizae uralensis attenuate methamphetamine-induced hyperlocomotor activity

Zhao¹,

Wang²,

Lin³

et al. 2014

Herbal Formula Science

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“…Naringenin chalcone (31), isolated from tomato skin extract, inhibited histamine release with an IC 50 [128] receptor, suggesting that this natural chalcone might be effective in blocking the reinforcing effects of cocaine [128].…”

Section: Miscellaneous Bioactivitiesmentioning

confidence: 99%

Trends in Utilization of the Pharmacological Potential of Chalcones

Batovska

Todorova²

2010

CCP

298

206

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Chalcones (1,3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act as attractants to the pollinators. As flavonoids, chalcones also play an important role in defense against pathogens and insects. A longstanding scientific research has shown that chalcones also display other interesting biological properties such as antioxidant, cytotoxic, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. Some lead compounds with various pharmacological properties have been developed based on the chalcone skeleton. Clinical trials have shown that these compounds reached reasonable plasma concentrations and did not cause toxicity. For these reasons, chalcones became an object of continued interest in both academia and industry. Nowadays, several chalcones are used for treatment of viral disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like food additives and cosmetic formulation ingredients. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to describe the recent efforts of scientists in pharmacological screening of natural and synthetic chalcones, studying the mechanisms of chalcone action and relevant structure-activity relationships. Put together, these activities aimed at synthesis of pharmacologically active chalcones and their analogs.

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“…Recently, effects of ISL on physiological or behavioral changes in response to psychostimulants have been reported. It has an inhibitory effect on cocaine-induced DA release in the nucleus accumbens of rat brain (8). ISL suppresses cocaine-induced behavioral changes such as locomotor activity.…”

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confidence: 99%

“…Intraperitoneal injections of ISL (20 mg/kg × 3) or vehicle were performed 30 min prior to the 1st and 3rd METH /saline injections and 24 h after the 1st ISL injection. Dose-response curves for ISL activity on DA release were previously reported, and the dose used for this study was derived from this prior work (8,9). Rectal temperature was recorded 30 min before the 1st and after the final METH injection, respectively.…”

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confidence: 99%

Protective Effects of Isoliquiritigenin Against Methamphetamine-Induced Neurotoxicity in Mice

Lee¹,

Yang²,

Jeon³

et al. 2009

J Pharmacol Sci

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Abstract. Isoliquiritigenin (ISL) suppresses cocaine-induced extracellular dopamine levels and has a neuroprotective effect in cocaine-treated rat brain. Here, we examine the effect of ISL on methamphetamine-induced striatal neurotoxicity. Repeated injections of methamphetamine cause the loss of striatal dopamine transporter (DAT) and tyrosine hydroxylase (TH). Intraperitoneal injection of ISL prior to methamphetamine injection significantly prevented methamphetamineinduced reduction of DAT and TH. ISL also suppressed methamphetamine-induced activation of glial cells. Moreover, ISL impeded the expression of nitric oxide synthase and the activation of NF-κB through blockage of its phosphorylation. Our results suggest that ISL protects against methamphetamine-induced neurotoxicity by inhibition of NF-κB activation.

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Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABAB receptor

Cited by 40 publications

References 30 publications

Methanol extract from radix of Glycyrrhizae uralensis attenuate methamphetamine-induced hyperlocomotor activity

Methanol extract from radix of Glycyrrhizae uralensis attenuate methamphetamine-induced hyperlocomotor activity

Trends in Utilization of the Pharmacological Potential of Chalcones

Protective Effects of Isoliquiritigenin Against Methamphetamine-Induced Neurotoxicity in Mice

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