Isomaltulose alleviates acute colitis <i>via</i> modulating gut microbiota and the Treg/Th17 balance in mice

Zhou, Zihan; Yu, Shengnan; Cui, Luwen; Shao, Kaidi; Pang, Hao; Wang, Zhipeng; He, Ningning; Li, Shangyong

doi:10.1039/d2fo01157c

Cited by 10 publications

(2 citation statements)

References 48 publications

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“…26,27 The findings of our previous studies suggest that various functional foods possess prebiotic properties by modulating the Treg/ Th17 cell balance. 28,29 On the other hand, there has been limited research on the impact of STA on the crucial pathogenic mechanism of Treg/Th17 balance in UC. In the present study, we initially assessed Treg and Th17 activities in DSS-induced colitis model mice treated with STA (Figure 3).…”

Section: ■ Discussionmentioning

confidence: 99%

Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway

He,

Chen,

et al. 2024

J. Agric. Food Chem.

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Ulcerative colitis (UC) is a complex chronic inflammatory disease closely associated with gut homeostasis dysfunction. The previous studies have shown that stachyose, a functional food additive, has the potential to enhance gut health and alleviate UC symptoms. However, the underlying mechanism of its effects remains unknown. In this study, our findings showed that dietary supplements of stachyose had a significant dose-dependent protective effect on colitis symptoms, regulation of gut microbiota, and restoration of the Treg/Th17 cell balance in dextran sulfate sodium (DSS) induced colitis mice. To further validate these findings, we conducted fecal microbiota transplantation (FMT) to treat DSS-induced colitis in mice. The results showed that microbiota from stachyose-treated mice exhibited a superior therapeutic effect against colitis and effectively regulated the Treg/Th17 cell balance in comparison to the control group. Moreover, both stachyose supplementation and FMT resulted in an increase in butyrate production and the activation of PPARγ. However, this effect was partially attenuated by PPARγ antagonist GW9662. These results suggested that stachyose alleviates UC symptoms by modulating gut microbiota and activating PPARγ. In conclusion, our work offers new insights into the benefical effects of stachyose on UC and its potential role in modulating gut microbiota.

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Section: ■ Discussionmentioning

confidence: 99%

Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway

He,

Chen,

et al. 2024

J. Agric. Food Chem.

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“…After grinding, the red blood cells were lysed and obtained single cell suspension. The specific method for measuring the number of T helper type 17 (Th17) cells and regulatory T (Treg) cells via flow cytometry referred to our previous study [ 57 ].…”

Section: Methodsmentioning

confidence: 99%

Polysaccharides from Paecilomyces hepiali Prevent Acute Colitis in Association with Modulating Gut Microbiota and Treg/Th17 Immune Balance in Mice

Cui

et al. 2023

Molecules

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Cordyceps exopolysaccharide (CEP) has shown emerging potential in adjustment of gut microbiota and immune cell function. In this study, a water-soluble CEP with a molecular weight of 58.14 kDa was extracted from the fermentation broth of Paecilomyces hepiali, an endophytic fungus of Cordyceps sinensis. Our results indicated that Paecilomyces hepiali polysaccharide (PHP) showed significantly preventive potential on dextran sulfate sodium (DSS)-induced colitis in mice, which can prevent colon shortening, reduce intestinal epithelial cell (IEC) destruction, suppress inflammatory cell infiltration, and regulate the balance between regulatory T (Treg) cells and T helper type 17 (Th17) cells. Meanwhile, the disturbed gut microbiota was partially restored after PHP treatment. Further Pearson correlation coefficient analyses exhibited that the alteration of the gut microbiota was significantly related to adjustment of the IEC barrier and Treg/Th17 balance. In conclusion, all findings proposed that purified PHP has the potential to develop into a promising agent for colitis prevention and adjuvant therapy via maintaining intestinal homeostasis of gut microbiota and immune system.

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Impact of artificial sweeteners and rare sugars on the gut microbiome

Lee,

So,

Yoo

et al. 2024

Food Sci Biotechnol

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Isomaltulose alleviates acute colitis via modulating gut microbiota and the Treg/Th17 balance in mice

Abstract: Food-grade isomaltulose exhibits significant modulation of gut microbiota and its metabolites in healthy populations. This study further explored preventive therapeutic effect and anti-colitis potential of isomaltulose on dextran sulfate sodium...

Cited by 10 publications

References 48 publications

Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway

Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway

Polysaccharides from Paecilomyces hepiali Prevent Acute Colitis in Association with Modulating Gut Microbiota and Treg/Th17 Immune Balance in Mice

Impact of artificial sweeteners and rare sugars on the gut microbiome

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