Isomaltulose: Recent evidence for health benefits

Shyam, Sangeetha; Ramadas, Amutha; Chang, Sui Kiat

doi:10.1016/j.jff.2018.07.002

Cited by 59 publications

(28 citation statements)

References 41 publications

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“…IM garnered attentions as an alternative sweetener to sucrose. IM is also involved in management and prevention of chronic diseases like cancers and cardio-metabolic diseases (Shyam et al, 2018). IM is mostly produced from sucrose by sucrose isomerase (SIase) (Zhang et al, 2018 using the cell wall protein (CWP) Pir1 and achieved 465 g/L IM production.…”

Section: Isomaltulosementioning

confidence: 99%

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Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Abbasi

Liu

Zhi

et al. 2021

Front. Bioeng. Biotechnol.

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The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as the predominant alternatives. The properties of Yarrowia lipolytica make it a promising sugar alcohol and functional sugar producer. However, there are still some issues to be resolved. As there exist reviews about the chemical structures, physicochemical properties, biological functions, applications, and biosynthesis of sugar alcohols and/or functional sugars in Y. lipolytica, this mini review will not only update the recent advances in enzymatic and microbial production of sugar alcohols (erythritol, D-threitol, and xylitol) and functional sugars (isomaltulose, trehalose, fructo-oligosaccharides, and galacto-oligosaccharides) by using recombinant Y. lipolytica but also focus on the studies of gene discovery, pathway engineering, expanding substrate scope, bioprocess engineering, and novel breeding methods to resolve the aforementioned issues.

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Section: Isomaltulosementioning

confidence: 99%

“…Isomaltulose (IM) is a disaccharide sugar usually present in nature. It consists of glucose and fructose monomers which are connected with each other through α-1,6 glycosidic linkage ( Shyam et al, 2018 ). The well-known trade name of IM is Palatinose TM .…”

Section: Production Of Sugar Alcohols and Functional Sugars In mentioning

confidence: 99%

Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Abbasi

Liu

Zhi

et al. 2021

Front. Bioeng. Biotechnol.

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“…Isomaltulose naturally occurs in honey and sugar cane juice [ 19 ]. Due to that, it exhibits many excellent properties, including similar organoleptic quality and processability to sucrose, low glycemic index, and non-cariogenicity; isomaltulose has been extensively used as sugar alternative in the food industry [ 20 ]. In our previous study, isomaltulose promoted the proliferation of selected probiotics [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Isomaltulose Exhibits Prebiotic Activity, and Modulates Gut Microbiota, the Production of Short Chain Fatty Acids, and Secondary Bile Acids in Rats

et al. 2021

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In vitro experiments have indicated prebiotic activity of isomaltulose, which stimulates the growth of probiotics and the production of short chain fatty acids (SCFAs). However, the absence of in vivo trials undermines these results. This study aims to investigate the effect of isomaltulose on composition and functionality of gut microbiota in rats. Twelve Sprague–Dawley rats were divided into two groups: the IsoMTL group was given free access to water containing 10% isomaltulose (w/w), and the control group was treated with normal water for five weeks. Moreover, 16S rRNA sequencing showed that ingestion of isomaltulose increased the abundances of beneficial microbiota, such as Faecalibacterium and Phascolarctobacterium, and decreased levels of pathogens, including Shuttleworthia. Bacterial functional prediction showed that isomaltulose affected gut microbial functionalities, including secondary bile acid biosynthesis. Targeted metabolomics demonstrated that isomaltulose supplementation enhanced cholic acid concentration, and reduced levels of lithocholic acid, deoxycholic acid, dehydrocholic acid, and hyodeoxycholic acid. Moreover, the concentrations of propionate and butyrate were elevated in the rats administered with isomaltulose. This work suggests that isomaltulose modulates gut microbiota and the production of SCFAs and secondary bile acids in rats, which provides a scientific basis on the use of isomaltulose as a prebiotic.

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“…It is an isomer of saccharose, which is also the substrate for commercial production by a biotechnological process using bacterial isomerases [ 1 , 2 , 3 ]. Unlike saccharose, isomaltulose lowers the glycemic index and shows additional health benefits [ 4 , 5 , 6 ]. Recently, isomaltulose has been shown to improve hyperglycemia in vivo [ 7 ] which has brought about related clinical trials [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid HPLC Method for Determination of Isomaltulose in the Presence of Glucose, Sucrose, and Maltodextrins in Dietary Supplements

Crha

Pazourek

2020

Foods

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This paper presents a rapid HPLC method for the separation of isomaltulose (also known as Palatinose) from other common edible carbohydrates such as sucrose, glucose, and maltodextrins, which are commonly present in food and dietary supplements. This method was applied to determine isomaltulose in selected food supplements for special diets and athletic performance. Due to the selectivity of the separation system, this method can also be used for rapid profiling analysis of mono-, di-, and oligosaccharides in food.

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Isomaltulose: Recent evidence for health benefits

Cited by 59 publications

References 41 publications

Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Isomaltulose Exhibits Prebiotic Activity, and Modulates Gut Microbiota, the Production of Short Chain Fatty Acids, and Secondary Bile Acids in Rats

Rapid HPLC Method for Determination of Isomaltulose in the Presence of Glucose, Sucrose, and Maltodextrins in Dietary Supplements

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