Mass measurements of neutron-rich Cd and Ag isotopes were performed with the Penning trap mass spectrometer ISOLTRAP. The masses of 112,[114][115][116][117][118][119][120][121][122][123][124]120,[122][123][124]126,128 Cd, determined with relative uncertainties between 2 × 10 −8 and 2 × 10 −7 , resulted in significant corrections and improvements of the mass surface. In particular, the mass of 124 Ag was previously unknown. In addition, other masses that had to be inferred from Q values of nuclear decays and reactions have now been measured directly. The analysis includes various mass differences, namely the two-neutron separation energies, the applicability of the Garvey-Kelson relations, double differences of masses δV pn , which give empirical proton-neutron interaction strengths, as well as a comparison with recent microscopic calculations. The δV pn results reveal that for even-even nuclides around 132 Sn the trends are similar to those in the 208 Pb region.