Isometamidium-dextran complex: Toxicity and activity against Trypanosoma vivax and Trypanosoma congolense in rats and mice

Chemotherapeutic control of trypanosomosis - a review of past measures, current status and future trends

“…to protect cattle against trypanosomosis and still yield good carcass and hide grading. The therapeutic index of the isometamidium-dextran complex was four times that of The therapeutic index of the isometamidium-dextran complex was four times that of isometamidium alone (ALIU and CHINEME (1980). The subcutaneous site of injection isometamidium alone (ALIU and CHINEME (1980).…”

“…The therapeutic index of the isometamidium-dextran complex was four times that of The therapeutic index of the isometamidium-dextran complex was four times that of isometamidium alone (ALIU and CHINEME (1980). The subcutaneous site of injection isometamidium alone (ALIU and CHINEME (1980). The subcutaneous site of injection of the complex tolerated a higher dose of isometamidium, with a resultant increase in the of the complex tolerated a higher dose of isometamidium, with a resultant increase in the prophylactic period (ALIU and SANNUSI, 1979;ALIU and CHINEME, 1980).…”

“…The authors attributed the prophylactic action of the drug to this intramuscular injection. The authors attributed the prophylactic action of the drug to this intramuscular depot, which becomes limited following encapsulation resulting from local tissue depot, which becomes limited following encapsulation resulting from local tissue reaction (ALIU and CHINEME, 1980). As a result of the known tissue reaction of ISMD reaction (ALIU and CHINEME, 1980).…”

“…The authors attributed the prophylactic action of the drug to this intramuscular depot, which becomes limited following encapsulation resulting from local tissue depot, which becomes limited following encapsulation resulting from local tissue reaction (ALIU and CHINEME, 1980). As a result of the known tissue reaction of ISMD reaction (ALIU and CHINEME, 1980). As a result of the known tissue reaction of ISMD K. I. Eghianruwa et al: Chemotherapeutic control of trypanosomosis -a review of past measures, current status and future trends at the intramuscular site of injection, OGUN and EGHIANRUWA, (1993) evaluated at the intramuscular site of injection, OGUN and EGHIANRUWA, (1993) evaluated the absorption rate of ISMD from the stomach and intestine of rats, and reported that the absorption rate of ISMD from the stomach and intestine of rats, and reported that ISMD was appreciably absorbed from the stomach and not from the intestine.…”

“…Studies involving the Isometamidium-dextran complex and isometamidium-of ISMD. Studies involving the Isometamidium-dextran complex and isometamidiumsuramin complex were undertaken in the late seventies and early eighties suramin complex were undertaken in the late seventies and early eighties ALIU and SANNUSI, 1979;ALIU and CHINEME, 1980), following the suggestion that ALIU and SANNUSI, 1979;ALIU and CHINEME, 1980), following the suggestion that complexation would alter the kinetics of absorption and lengthen the prophylactic period. complexation would alter the kinetics of absorption and lengthen the prophylactic period.…”