Isometric handgrip exercise training reduces resting systolic blood pressure but does not interfere with diastolic blood pressure and heart rate variability in hypertensive subjects: a systematic review and meta-analysis of randomized clinical trials

Almeida, João Pedro Arantes de Sousa; Bessa, Murilo; Lopes, Leandro Teixeira Paranhos; Gonçalves, Alexandre; Roever, Leonardo; Zanetti, Hugo Ribeiro

doi:10.1038/s41440-022-00883-7

Cited by 8 publications

(7 citation statements)

References 6 publications

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“…Among these studies, the vast majority (76.5%) performed the handgrip, followed by knee extension (13.7%) (Table 1, Ref. [8,13,[18][19][20]22,23,).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Otherwise, the isometric handgrip training has been used to improve cardiovascular health [7][8][9], given the reduction in blood pressure (BP) and improvement in endothelial function after a few weeks of intervention. The most commonly used handgrip protocol consists of four two-minute sets of contractions at 30% of maximal voluntary contraction (MVC) with a recovery interval of one to four minutes [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis

CONEGLIAN¹,

BARCELOS²,

BANDEIRA³

et al. 2023

Rev. Cardiovasc. Med.

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Background: This study aimed to identify the blood pressure (BP) responses during different types of isometric exercises (IE) in adults and to evaluate whether BP responses according to IE is influenced by the characteristics of participants and exercise protocols. Methods:The search was conducted in PubMed, Cochrane Central, SPORTDiscus, and LILACS databases in June 2020. Random effects models with a 95% confidence interval and p < 0.05 were used in the analyses. Results: Initially, 3201 articles were found and, finally, 102 studies were included in this systematic review, seven of which were included in the meta-analysis comparing handgrip to other IE. Twoknee extension and deadlift promoted greater increases in systolic (+9.8 mmHg; p = 0.017; I 2 = 74.5% and +26.8 mmHg; p ≤ 0.001; I 2 = 0%, respectively) and diastolic (+7.9 mmHg; p = 0.022; I 2 = 68.6% and +12.4 mmHg; p ≤ 0.001; I 2 = 36.3%, respectively) BP compared to handgrip. Men, middle-aged/elderly adults, hypertensive individuals, and protocols with higher intensities potentiate the BP responses to handgrip exercise (p ≤ 0.001). Conclusions: IE involving larger muscle groups elicit greater BP responses than those involving smaller muscle masses, especially in men, middle-aged/elderly adults and hypertensive individuals. Future studies should directly compare BP responses during various types of IE in different populations.

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“…Among these studies, the vast majority (76.5%) performed the handgrip, followed by knee extension (13.7%) (Table 1, Ref. [8,13,[18][19][20]22,23,).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis

CONEGLIAN¹,

BARCELOS²,

BANDEIRA³

et al. 2023

Rev. Cardiovasc. Med.

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“…A recent meta-analysis demonstrated that IHT reduces SBP and DBP by À7.1 (À9.5 to À4.7) and À3.5 (À5.2 to À1.7) mmHg, respectively, after 8-12 weeks of training [5]. However, the interindividual variability to the BP-lowering effect of IHT varies among hypertensive patients [6,7], suggesting that factors related to the patients' baseline characteristics may affect this response. Along this line, some evidence suggests that patients with a lower baseline BP respond less favorably to IHT compared with those with a higher baseline BP [8,9].…”

Section: Introductionmentioning

confidence: 99%

Characteristics associated with responsiveness to isometric handgrip training in medicated hypertensive patients: secondary data analysis

Farah,

Forjaz,

O’Driscoll

et al. 2024

Journal of Hypertension

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Objective: Isometric handgrip training (IHT) has been shown to reduce blood pressure (BP) in hypertensive patients. However, factors that predict responsiveness to IHT are largely unknown. The aim of this study was to investigate the patient characteristics associated with the antihypertensive response to IHT using a recommended statistical approach for evaluating interindividual responses. Methods: Data from four randomized controlled trials were joined, totaling 81 patients undergoing IHT (48.8% women; 60 ± 11 years) and 90 control patients (45.6% women; 62 ± 12 years). IHT consisted of 4 × 2 min isometric contractions at 30% of maximal voluntary contraction, performed three times/week for 8–12 weeks. BP was measured at baseline and following IHT and control interventions. The interindividual variation was assessed by the standard deviation of the individual responses (SDir), and linear regression analyses were conducted to explore response predictors. Results: IHT significantly decreased both SBP (−5.4; 95% confidence interval (CI) −9.5 to −1.3 mmHg) and DBP (−2.8; 95% CI −5.1 to −0.6 mmHg). The interindividual variation of BP change was moderate for systolic (SDir = 5.2 mmHg, 0.30 standardized units) and low for diastolic (SDir = 1.7 mmHg, 0.15 standardized units). Sex, age, and BMI were not associated with the antihypertensive effect of IHT. However, a higher baseline SBP (b = −0.467, P < 0.001) and absence of dihydropyridine calcium channel blockers use (b = 0.340, P = 0.001) were associated with greater BP reductions. Conclusion: IHT reduced BP in medicated hypertensive patients regardless of age, sex, and BMI. Patients with a higher baseline SBP and those not prescribed dihydropyridine calcium channel blockers were more responsive to IHT.

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“…SDNN, RMSSD e PNN50) (FARAH et al, 2020) e da frequência (i.e. BFR-R, AHFR-R, BF/AFR-R) (ALMEIDA et al, 2021;FARAH et al, 2020) na população em geral (FARAH et al, 2020) e nem hipertensos (ALMEIDA et al, 2021). Portanto, os presentes resultados, em conjunto com a literatura mais recente, contestam a hipótese de que o efeito hipotensor TRI_h estaria relacionado a alterações autonômicas promovidas por esse treinamento, embora ainda seja importante reconhecer a necessidade de estudos futuros que avaliem o efeito do TRI_h na atividade nervosa simpática periférica de hipertensos através da medida direta dessa atividade.…”

Section: Treinamento Isométrico De Handgripunclassified

“…Mais recentemente, o efeito hipotensor do TRI_h tem atraído a atenção dos pesquisadores. Uma metanálise recente (ALMEIDA et al, 2021) sobre esse assunto constatou redução da PAS, na ordem de -8,1 mmHg, após esse treinamento em hipertensos. No entanto, novamente, os mecanismos responsáveis por esse efeito não estão claros.…”

Section: Introductionunclassified

Efeitos do treinamento resistido dinâmico, isométrico e combinado (Dinâmico + Isométrico) na função e regulação cardiovascular de repouso e pós-exercício em homens hipertensos medicados

Fécchio¹

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Moraes Forjaz, por acreditar em mim e por dar todo apoio necessário para realização desse projeto. E especialmente, pelos ensinamentos ao longo dos últimos 13 anos. Espero levar adiante o seu modus operandi marcado por disciplina, empenho, precisão, coerência, rigor metodológico, integridade, empatia e busca pelo conhecimento.Aos meus pais, pelo apoio e incentivo durante todo esse processo e pela educação e carinho que sempre recebi. Agradeço também ao meu irmão Daniel pelo companheirismo e amizade.À minha parceira, Amanda, por estar sempre ao meu lado, nos bons e maus momentos. Cada alegria e cada dificuldade deste processo foi dividida com você. Te amo.A todos os colegas do Laboratório de Hemodinâmica da Atividade Motora, em especial ao Júlio. Agradeço também por ter tido excelentes exemplos acadêmicos, os alunos mais antigos do laboratório, Leandro e Tiago.

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Isometric handgrip exercise training reduces resting systolic blood pressure but does not interfere with diastolic blood pressure and heart rate variability in hypertensive subjects: a systematic review and meta-analysis of randomized clinical trials

Cited by 8 publications

References 6 publications

Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis

Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis

Characteristics associated with responsiveness to isometric handgrip training in medicated hypertensive patients: secondary data analysis

Efeitos do treinamento resistido dinâmico, isométrico e combinado (Dinâmico + Isométrico) na função e regulação cardiovascular de repouso e pós-exercício em homens hipertensos medicados

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