Isoniazid@Fe<sub>2</sub>O<sub>3</sub>‐Nanocontainer mit antibakterieller Wirkung auf Tuberkulose‐Mykobakterien

Leidinger, Peter; Treptow, Jens; Hagens, Kristine; Eich, Jacqueline; Zehethofer, Nicole; Schwudke, Dominik; Oehlmann, Wulf; Lünsdorf, Heinrich; Goldmann, Oliver; Schaible, Ulrich E.; Dittmar, Kurt E.J.; Feldmann, Claus

doi:10.1002/ange.201505493

Cited by 11 publications

(18 citation statements)

References 40 publications

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“…TheH 2 O 2driven oxidation of Fe(CO) 5 results in the formation of Fe 2 O 3 at the liquid-liquid phase boundary of the ME (Figure 14). [65] These cells,o nt he one hand, show ah igh uptake rate of nanoparticles,a nd on the other hand, af ast response to putatively toxic compounds. Fourrier-transform infrared spectroscopy (FTIR) and mass spectrometry (MS) prove the presence of INH;thermogravimetric analysis (TGA) indicates an INH load of 48 wt %a s well as 9wt% water (cavity filling) and 43 wt %F e 2 O 3 (sphere wall).…”

Section: Nanocontainers For Drug Deliverysupporting

confidence: 64%

“…[76] INH@Fe 2 O 3 hollow nanospheres were synthesized from as tandard w/o-ME comprising water, n-dodecane,C TAB, and 1-hexanol. [65] According to electron microscopy studies,t he INH@Fe 2 O 3 nanocontainers have am ean outer diameter of 18 AE 1nm, aw all thickness of 2-4 nm, and an inner cavity of 8-10 nm. In addition, Fe(CO) 5 was added to the dodecane phase as al ipophilic reactant.…”

Section: Nanocontainers For Drug Deliverymentioning

confidence: 99%

“…Au [47] 20-40/25-50 dodecane [b] n-C 12 H 25 SH water [b] HAuCl 4 4H 2 O Ag [61] 10-15/15-20 water NaBH 4 dodecane [Ag(PPh 3 ) 4 ]NO 3 AlO(OH) [62] 20-25/30-35 water dodecane Al(O s C 4 H 9 ) 3 La(OH) 3 [63] 2-17/10-30 water/KF [c] dodecane La(Cp) 3 ZnO [64] 2-4/6-8 water/NH 3 toluene Zn(Cp*) 2 Fe 2 O 3 [65] 15-20/25-35 water/ gelatin [c] dodecane TiCl 4 ZrO 2 [68] 6-12/10-20 water/ gelatin [c] dodecane Zr(O t C 4 H 9 ) 4 Cu 2 S [69] 8 …”

Section: Dispersant Phasementioning

confidence: 99%

“…[74] Thesynthesis,size, and properties of these systems,h owever, are significantly different from the hollow nanospheres discussed here.Therefore,t he interested reader is referred to recent reviews. [75] In the following we address drug transport and drug release with two examples: 1) isoniazid-filled (isonicotinylhydrazine,I NH) iron oxide hollow nanopheres (INH@Fe 2 O 3 )f or treatment of tuberculosis (TB), [65] 2) doxorubicin-filled (DOX) aluminum oxide hydroxide hollow nanospheres (DOX@AlO(OH)) for treatment of cancer. [75] In the following we address drug transport and drug release with two examples: 1) isoniazid-filled (isonicotinylhydrazine,I NH) iron oxide hollow nanopheres (INH@Fe 2 O 3 )f or treatment of tuberculosis (TB), [65] 2) doxorubicin-filled (DOX) aluminum oxide hydroxide hollow nanospheres (DOX@AlO(OH)) for treatment of cancer.…”

Section: Nanocontainers For Drug Deliverymentioning

confidence: 99%

“…[65] Such passive and slow release of INH from the nanocontainers is another advantage for TB therapy. [65] Such passive and slow release of INH from the nanocontainers is another advantage for TB therapy.…”

Section: Nanocontainers For Drug Deliverymentioning

confidence: 99%

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Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles

Wolf

Feldmann

2016

Angew Chem Int Ed

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Microemulsions (MEs) are ideal for obtaining high-quality inorganic nanoparticles. As thermodynamically stable systems with a nanometer-sized droplet phase that serves as a nanoreactor, MEs have obvious advantages for the synthesis of nanoparticles. MEs also have disadvantages, such as their complexity as multicomponent systems, the low amount of obtainable nanoparticles, their limited thermal stability, the fact that hydrolyzable or oxidizable compounds are often excluded from synthesis, the partly elaborate separation of nanoparticles, as well as the removal of surface-adhered surfactants subsequent to synthesis. This Review presents some strategies to further expand the options of ME-based synthesis of inorganic nanoparticles. This comprises the crystallization of nanoparticles in "high-temperature MEs", the synthesis of hollow nanospheres, the use of hydrogen peroxide or liquid ammonia as the polar droplet phase, and the synthesis of base metals and nitrides in MEs.

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Section: Nanocontainers For Drug Deliverysupporting

confidence: 64%

Section: Nanocontainers For Drug Deliverymentioning

confidence: 99%

Section: Dispersant Phasementioning

confidence: 99%

Section: Nanocontainers For Drug Deliverymentioning

confidence: 99%

Section: Nanocontainers For Drug Deliverymentioning

confidence: 99%

See 3 more Smart Citations

Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles

Wolf

Feldmann

2016

Angew Chem Int Ed

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Mikroemulsionen: neue Möglichkeiten zur Erweiterung der Synthese anorganischer Nanopartikel

Wolf

Feldmann

2016

Angewandte Chemie

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Mikroemulsionen (ME) sind ideal, um hochwertige anorganische Nanopartikel zu erhalten. Als thermodynamisch stabile Systeme mit einer Phase aus Nanometer‐großen Tröpfchen, die als Nanoreaktoren dienen, bieten sie für die Nanopartikelsynthese eine Reihe an Vorteilen. ME haben aber auch Nachteile, z. B. ihre Komplexität als Mehrkomponentensysteme, die geringe erhältliche Nanopartikelmenge, die begrenzte thermische Stabilität, der häufige Ausschluss hydrolysierbarer oder oxidierbarer Verbindungen von der Synthese, die partiell sehr aufwendige Abtrennung der Nanopartikel sowie die Entfernung Oberflächen‐gebundener Tenside nach der Synthese. Dieser Aufsatz soll einige Strategien zur Erweiterung der ME‐basierten Synthese anorganischer Nanopartikel aufzeigen. Dazu zählen die Kristallisation von Nanopartikeln mittels “Hochtemperatur‐ME”, die Synthese nanoskaliger Hohlkugeln, die Verwendung von H2O2 oder flüssigem NH3 als polare Tröpfchenphasen sowie die Synthese von unedlen Metallen und Nitriden in ME.

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Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

Liu

Tong

et al. 2018

Angewandte Chemie

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Cancer hallmarks allowt he complexity and heterogeneity of tumor biology to be better understood, leading to the discovery of various promising targets for cancer therapy. An amorphous iron oxide nanoparticle (NP)-based RNAi strategy is developed to co-target two cancer hallmarks.T he NP technology can modulate the glycolysis pathway by silencing MCT4 to induce tumor cell acidosis,a nd concurrently exacerbate oxidative stress in tumor cells via the Fenton-like reaction. This strategy has the following features for systemic siRNAd elivery:1 )siRNAe ncapsulation within NPs for improving systemic stability;2 )effective endosomal escape through osmotic pressure and/or endosomal membrane oxidation;3 )small sizef or enhancing tumor tissue penetration; and 4) triple functions (RNAi, Fenton-like reaction, and MRI) for combinatorial therapya nd in vivo tracking.Scheme 1. Illustration of A) the formulation and B) multiple functions of AIO RNAi NPs.

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Isoniazid@Fe₂O₃‐Nanocontainer mit antibakterieller Wirkung auf Tuberkulose‐Mykobakterien

Cited by 11 publications

References 40 publications

Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles

Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles

Mikroemulsionen: neue Möglichkeiten zur Erweiterung der Synthese anorganischer Nanopartikel

Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

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Isoniazid@Fe2O3‐Nanocontainer mit antibakterieller Wirkung auf Tuberkulose‐Mykobakterien

Cited by 11 publications

References 40 publications

Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles

Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles

Mikroemulsionen: neue Möglichkeiten zur Erweiterung der Synthese anorganischer Nanopartikel

Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

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Resources

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Isoniazid@Fe₂O₃‐Nanocontainer mit antibakterieller Wirkung auf Tuberkulose‐Mykobakterien