Isoniazid-induced recurrent acute pancreatitis

Pandey, Arvind S; Surana, Ashish

doi:10.1258/td.2011.110127

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…Isoniazid is an antitubercular antibiotic that inhibits cell wall synthesis and acts specifically on the synthesis of mycolic acids, which are essential components of the cell wall of the bacterium Mycobacterium tuberculosis [102].…”

Section: Isoniazidmentioning

confidence: 99%

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Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Del Gaudio,

Covello,

Di Vincenzo

et al. 2023

Antibiotics

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Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence. We reviewed the available data on drug-induced AP, focusing on antimicrobial drugs and antivirals, and discussed the current evidence in relation to the classification systems available in the literature. We found 51 suspected associations between antimicrobial and antiviral drugs and AP. The drugs with the most evidence of correlation are didanosine, protease inhibitors, and metronidazole. In addition, other drugs have been described in case reports demonstrating positive rechallenge. However, there are major differences between the various classifications available, where the same drug being assigned to different probability classes. It is likely that the presence in multiple case reports of an association between acute pancreatitis and a drug should serve as a basis for conducting prospective randomized controlled trials to improve the quality of the evidence.

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Section: Isoniazidmentioning

confidence: 99%

“…Isoniazid has been associated with pancreatitis in several patients, either during chemoprophylaxis or the treatment of tuberculosis [102][103][104][105][106][107][108][109][110][111][112][113][114]. A positive rechallenge was described in a total of seven patients, with other causes excluded in seven patients.…”

Section: Isoniazidmentioning

confidence: 99%

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Del Gaudio,

Covello,

Di Vincenzo

et al. 2023

Antibiotics

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show abstract

“…In Malawi gallstones are rare and more common etiologies include alcohol consumption and medications (such as isoniazid and stavudine). 3,4 A distinct entity, tropical pancreatitis, is seen among young individuals during prolonged periods of decreased food intake particularly in warm climates. 5 Acute pancreatitis can be recurrent.…”

Section: Introductionmentioning

confidence: 99%

A case of acute necrotizing pancreatitis: Practical and ethical challenges of a North–South partnership

Samuel

Ludzu

Cairns

et al. 2013

International Journal of Surgery Case Reports

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INTRODUCTIONThe Departments of Surgery at the University of North Carolina (UNC) and Kamuzu Central Hospital (KCH) in Lilongwe, Malawi, formed a partnership of service, training, and research in 2008. We report a case of recurrent pancreatitis leading to pancreatic necrosis treated at KCH.PRESENTATION OF CASEA 42 year-old male presented to KCH with his fourth episode of abdominal pain, nausea and vomiting. He had tachycardia, guarding, rebound tenderness, and free fluid on abdominal ultrasonography. He underwent laparotomy and had fat saponification with pancreatic necrosis. A large drain was placed, he was given antibiotics, and he recovered. He had normal lipids, no gallstones, and did not consume alcohol. He was encouraged to seek further evaluation with endoscopic retrograde cholangiopancreatography or computed tomography in South Africa, however this was prohibitively expensive.DISCUSSIONThis case illustrates the limitations that are often faced by surgeons visiting developing countries. What we consider standard resources and treatment algorithms in managing necrotizing pancreatitis in developed countries (such as serum lipase and percutaneous interventions) were not available.CONCLUSIONVisiting surgeons and trainees must be both familiar with local resource limitations and aware of the implications of such limitations on patient care. To support training and promote advances in health care, local surgeons and trainees should understand optimal treatment strategies regardless of their particular resource limitations. North–South partnerships are an excellent means to uphold our professional obligation to humanity, promote health care as a right, and shape the future of health care in developing countries.

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Isoniazid-induced pancreatitis: A systematic review

Baral,

Thomas

et al. 2024

Tuberculosis

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Isoniazid-induced recurrent acute pancreatitis

Cited by 6 publications

References 3 publications

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

A case of acute necrotizing pancreatitis: Practical and ethical challenges of a North–South partnership

Isoniazid-induced pancreatitis: A systematic review

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