Isoniazid prophylaxis for tuberculosis prevention among HIV infected police officers in Dar Es Salaam

Bakari, Muhammad; Moshi, A.; Aris, Emmanuel; Chale, Stella; Josiah, R.; Magao, P.; Pallangyo, N.; Mugusi, F; Sandström, Eric; Biberfeld, Gunnel; Mhalu, Fred; Pallangyo, Kisali

doi:10.4314/eamj.v77i9.46695

Cited by 9 publications

(18 citation statements)

References 14 publications

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“…This may be because the level of adherence in the South African study was measured by more objective method that involved a biochemical test called the Arkansas method, where a chemical reaction with urinary INH metabolites produces a visible blue color change and self-report method. In general the level of nonadherence 10.5% is good and acceptable when compared with other studies reported having so far nonadherence level ranging from 14 to 38% [19][20][21][22][23][24]. In the multivariate analysis, patients who took IPT for ≥5 months were more likely to be adherent than those who took it for 1-2 months.…”

Section: Discussionmentioning

confidence: 67%

Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia

Berhe¹,

Demissie

Tesfaye

2014

Advances in Epidemiology

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Tuberculosis coinfected with HIV constitutes a large proportion of patients in Ethiopia. Isoniazid preventive therapy (IPT) is recommended for the treatment of latent tuberculosis infection. However, the level of IPT adherence and associated factors among people living with HIV (PLHIV) have not been well explored. This study aimed to assess adherence to IPT and associated factors among PLHIV in Addis Ababa. Facility based cross-sectional study was conducted. The study was conducted in 10 health centers and 2 hospitals. Patients were consecutively recruited till the required sample size was obtained. From 406 PLHIV approached, a total of 381 patients on IPT were interviewed. Data were entered and analyzed using Epi-Info version 3.5 and SPSS version 16. The level of adherence to IPT was 89.5%. Patients who have taken isoniazid for ≥5 months were more likely to be adherent than those who took it for 1-2 months [AOR (95%CI) = 5.09 (1.41-18.36)]. Patients whose friends decide for them to start IPT were less likely to be adherent than others [AOR (95%CI) = 0.10 (0.01-0.82)]. The level of adherence to IPT in PLHIV was high. Counseling of patients who are in their first two months of therapy should be more strengthened. Strong Information Education Communication is essential to further enhance adherence.

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Section: Discussionmentioning

confidence: 67%

Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia

Berhe¹,

Demissie

Tesfaye

2014

Advances in Epidemiology

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“…In one study, a significant difference was noted between regimens, primarily in the duration of benefit, with continued efficacy noted at 3 years for the rifamycin-based regimens but not for standard IPT. 16 Five additional studies reported on TB incidence in adults without a comparison group; 38,39,48,51–53 findings from these are included in Table S1 (See Supplemental Digital content).…”

Section: Resultsmentioning

confidence: 99%

Use of Isoniazid Preventive Therapy for Tuberculosis Prophylaxis Among People Living With HIV/AIDS

Briggs

Emerson

Modi

et al. 2015

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…The apparently relatively poor quality of some studies was directly attributable to the poorer quality of their reporting [23], [24]. All studies performed well for applicability, with the exception of one study which was limited to a police officer population [19]. The utility of this particular study was further limited in only including analysis of factors for acceptance of enrolment in IPT and not factors for adherence or non adherence after commencement of the medication.…”

Section: Resultsmentioning

confidence: 99%

Factors Associated with Adherence to Treatment with Isoniazid for the Prevention of Tuberculosis amongst People Living with HIV/AIDS: A Systematic Review of Qualitative Data

2014

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ObjectiveTo systematically identify from qualitative data in the published literature the main barriers to adherence to isoniazid preventive therapy (IPT) for tuberculosis (TB) among people living with HIV/AIDS (PLWHA).MethodsWe searched ten data sources, including MEDLINE and EMBASE for articles published in peer-reviewed journals from inception through to December 2011 for evidence relevant to IPT for TB in relation to PLWHA. Studies were assessed for quality using the CASP critical appraisal tool for qualitative studies. Data extracted from studies were then analysed thematically using thematic synthesis.ResultsEight studies, two of which were conducted within the same clinical trial, met the inclusion criteria. In addition to the influence of personal characteristics, five overarching themes were identified: Individual personal beliefs; HIV treatment and related issues; Socio-economic factors; Family and other social support factors, and Relationships with health providers. The review confirms current understanding of adherence to treatment as influenced by patients' understanding of, and beliefs related to treatment regimens. This is in-turn influenced by broader factors, namely: socio-economic factors such as poverty and lack of health facilities; the level of support available to patients from family and other networks and the stigma that emanates from these relationships; and relationships with health providers, which in-turn become a delicate issue given the sensitivity of dealing with two chronic diseases of significant morbidity and mortality toll. HIV treatment related issues also influence adherence to IPT, whereby challenges related to the acceptance, organisation and administration of these two long-term treatment regimens and stigma related to HIV/AIDS, are seen to be major factors.ConclusionUnderstanding this complex interplay of factors more clearly is essential for healthcare decision-makers to be able to achieve the level of adherence required to effectively mitigate the threat posed by co-infection with TB and HIV/AIDS in developing countries.

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Isoniazid prophylaxis for tuberculosis prevention among HIV infected police officers in Dar Es Salaam

Cited by 9 publications

References 14 publications

Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia

Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia

Use of Isoniazid Preventive Therapy for Tuberculosis Prophylaxis Among People Living With HIV/AIDS

Factors Associated with Adherence to Treatment with Isoniazid for the Prevention of Tuberculosis amongst People Living with HIV/AIDS: A Systematic Review of Qualitative Data

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