Isoporphyrin Intermediate in Heme Oxygenase Catalysis

Evans, John P.; Niemevz, Fernando; Buldain, Graciela; Montellano, Paul R. Ortiz de

doi:10.1074/jbc.m709685200

Cited by 30 publications

(18 citation statements)

References 48 publications

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“…The β -to-β butadiyne-bridged IP tetramers (23) and meso-tomeso butadiyne-bridged IP tetramers have been studied. The corresponding ZnIP compounds have not been considered because they have a net charge of +4 as each ZnP moiety has a charge of +1.…”

Section: Free-base Isoporphyrin Tetramersmentioning

confidence: 99%

Calculations of current densities and aromatic pathways in cyclic porphyrin and isoporphyrin arrays

Franzke

Sundholm

Weigend

2017

Phys. Chem. Chem. Phys.

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Magnetically induced current density susceptibilities have been studied for a number of cyclic ethyne- and butadiyne-bridged porphyrin and isoporphyrin arrays. The current density susceptibilities have been calculated using the gauge-including magnetically induced current (GIMIC) method, which is interfaced to the TURBOMOLE quantum chemistry code. Aromatic properties and current pathways have been analyzed and discussed by numerical integration of the current density susceptibilities passing selected chemical bonds yielding current strength susceptibilities. Despite the interrupted π-framework, zinc(ii) isoporphyrin sustains a ring current of ca. 10 nA T. Porphyrin and isoporphyrin dimers sustain a significant current strength at the linker, whereas the larger porphyrinoid arrays sustain mainly local ring currents. Isoporphyrin dimers with saturated meso carbons have strong net diatropic ring-current strengths of 20 nA T fulfilling Hückels aromaticity rule. Porphyrin trimers and tetramers exhibit almost no current strength at the linker. The porphyrin moieties maintain their strong net diatropic ring current.

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Section: Free-base Isoporphyrin Tetramersmentioning

confidence: 99%

Calculations of current densities and aromatic pathways in cyclic porphyrin and isoporphyrin arrays

Franzke

Sundholm

Weigend

2017

Phys. Chem. Chem. Phys.

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“… 42 Heme oxygenase is an enzyme that catalyzes the degradation of heme and produces biliverdin, iron, and carbon monoxide. 43 – 45 Biliverdin is subsequently converted to bilirubin by biliverdin reductases . Iron is an essential nutrient required for the survival of most bacteria.…”

Section: Discussionmentioning

confidence: 99%

A Metagenomic Analysis of Bacterial Microbiota in the Digestive Tract of Triatomines

Carels

Gumiel

Mota

et al. 2017

Bioinform Biol Insights

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The digestive tract of triatomines (DTT) is an ecological niche favored by microbiota whose enzymatic profile is adapted to the specific substrate availability in this medium. This report describes the molecular enzymatic properties that promote bacterial prominence in the DTT. The microbiota composition was assessed previously based on 16S ribosomal DNA, and whole sequenced genomes of bacteria from the same genera were used to calculate the GC level of rare and prominent bacterial species in the DTT. The enzymatic reactions encoded by coding sequences of both rare and common bacterial species were then compared and revealed key functions explaining why some genera outcompete others in the DTT. Representativeness of DTT microbiota was investigated by shotgun sequencing of DNA extracted from bacteria grown in liquid Luria-Bertani broth (LB) medium. Results showed that GC-rich bacteria outcompete GC-poor bacteria and are the dominant components of the DTT microbiota. In addition, oxidoreductases are the main enzymatic components of these bacteria. In particular, nitrate reductases (anaerobic respiration), oxygenases (catabolism of complex substrates), acetate-CoA ligase (tricarboxylic acid cycle and energy metabolism), and kinase (signaling pathway) were the major enzymatic determinants present together with a large group of minor enzymes including hydrogenases involved in energy and amino acid metabolism. In conclusion, despite their slower growth in liquid LB medium, bacteria from GC-rich genera outcompete the GC-poor bacteria because their specific enzymatic abilities impart a selective advantage in the DTT.

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“…The aspartic protease studied here is one of the factors involved in decolourisation. To completely decolourise myoglobin and haemoglobin, other enzymes such as oxygenase for haem and oxidoreductase for ferrous ion are probably required. We are currently searching for other enzymes involved in the decolourisation in Aspergillus species.…”

Section: Discussionmentioning

confidence: 99%

Aspartic protease from Aspergillus (Eurotium) repens strain MK82 is involved in the hydrolysis and decolourisation of dried bonito (Katsuobushi)

et al. 2012

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Isoporphyrin Intermediate in Heme Oxygenase Catalysis

Cited by 30 publications

References 48 publications

Calculations of current densities and aromatic pathways in cyclic porphyrin and isoporphyrin arrays

Calculations of current densities and aromatic pathways in cyclic porphyrin and isoporphyrin arrays

A Metagenomic Analysis of Bacterial Microbiota in the Digestive Tract of Triatomines

Aspartic protease from Aspergillus (Eurotium) repens strain MK82 is involved in the hydrolysis and decolourisation of dried bonito (Katsuobushi)

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