Isoprenoids obtained from Cortex Dictamni and their nitric oxide inhibitory activities

Zheng, Dandan; Sun, Fan; Wang, Huimei; Yang, Shuxu; Ruan, Jing; He, Wei; Wang, Jianli; Guo, Yuanqiang; Zhang, Yi; Wang, Tao

doi:10.1016/j.fitote.2019.104358

Cited by 2 publications

(2 citation statements)

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“…S3-3), compound 3 displayed 32 carbons, including six methyls, eleven methylenes, nine methines, and six quaternary carbons. The structure of compound 3 was similar to dictamtriterpenol A [4]. The difference was the substituent of C-2 of compound 3 was a hydroxyl group, and there was an ethoxyl group on C-25.…”

Section: Resultsmentioning

confidence: 94%

“…As a traditional Chinese medicine "Baixianpi", the root bark of D. dasycarpus was used for the treatment of cancer, infection, eczema, and so on [1]. As well as D. dasycarpus showed a variety of significant anti-inflammatory, anti-cancer, and antioxidant activities [2][3][4]. Meanwhile, the phytochemical studies of D. dasycarpus have revealed the presence of limonoids, alkaloids, sesquiterpenes, flavonoids, and triterpenoids [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Undescribed triterpenoids obtained from Dictamnus dasycarpus Turcz and their anti-proliferation activities

sun,

liu,

wang

et al. 2023

Preprint

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Three new triterpenoids, named dictamtriterpenol B-D (1-3), along with ten known compounds (4-13), were isolated from Dictamnus dasycarpus Turcz. The structures of all compounds were characterized by spectroscopic methods, including IR, HR-ESI-MS, 1D and 2D NMR. Furthermore, HepG2 and A549 cell lines were used to evaluate their anti-proliferation activities. And compounds 1, 5, and 8 (IC50 values in the range of 1.84±0.03 to 14.98±0.39 μM) displayed significant anti-proliferation activity against HepG2 cells. As well as compounds 1, 4, 9, 10, and 13 (IC50 values in the range of 1.63±0.04 to 8.56±1.46 μM) displayed significant anti-proliferation activity against A549 cells.

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Section: Resultsmentioning

confidence: 94%