Isopropylmagnesium Bromide

Direct access to 2-aryl substituted pyrrolinium salts for carbon centre based radicals without pyrrolidine-2-ylidene alias cyclic(alkyl)(amino)carbene (CAAC) as a precursor

“…Herein, we have considered a new strategy where 2-substituted pyrrolinium salts, V , can be generated from a secondary ketimine, VII , which has only one α-hydrogen, and a compound having geminal electrophilic centres, VIII . The secondary ketimine, VII , can be obtained in three very convenient steps (Scheme 2), from commercially available reagents: acid chloride, IX ; primary amine, X ; and secondary Grignard reagents, R 2 CHMgX, XI 11. In this strategy, there is a huge scope for variation at all the C -centres as well as at the N -centre of the pyrrolinium ring.…”