Isoproterenol continuous inhalation therapy in an infant with severe bronchiolitis lifesaving therapy

Abstract

Continuous inhalation of L-isoproterenol is safe and effective for the treatment of severe asthma in Japan. It has minimal effect on the heart rate and shows few or no toxic effects. 1 The effect of bronchodilators is considered controversial in patients with bronchiolitis. We treated a 46-day-old infant with bronchiolitis in whom the continuous inhalation of L-isoproterenol was very effective.

Neutrophil‐mediated inflammation in respiratory syncytial viral bronchiolitis

“…These drugs do not dilate the smaller bronchial radicles (bronchioles) but they could modulate neutrophil functions 29–33 and thus, suppress neutrophil‐mediated inflammation in RSV infection. Isoproterenol inhalation therapy for infantile severe bronchiolitis is also evaluated for the actions in the cardiovascular system rather than the action of the bronchodilator 34 .…”