Isoproterenol-induced lymphocyte-dependent salivary gland hyperplasia in mice: A possible analog of syngeneic mixed lymphocyte culture in vivo

A New Look At the Origin of the Immune System and New Immune Theory of Aging: Lymphocyte Regulation of Cellular Growth of Somatic Tissues: (History and Modern Concepts)

“…[13][14][15]. It was shown also that signs of bone tissue growth-osteoporosis are corrected by transfer of lymphocytes from healthy animals; moreover, parathyroid hormone, which is specific for osteoblast, produces the effect through T-lymphocytes, which have receptors to this hormone unlike the osteoblast [16].…”

“…The science of immunology presents thorough studies and detailed descriptions of the so-called "Syngenic Mixed Lymphocyte Culture" (sMLC), when T-cells, mainly of the T-helper and T-suppressor type, show a vigorous proliferation in response to the organism's own cells, including nonimmune ones; these are "surplus" cells in classical immunology and they can be removed by antisera without changes in the ordinary immune reactions [13,21,22].…”

"Lymphocyte Regulation of Cellular Growth of Somatic Tissues: A New Look at the Origin of the Immune System and New Immune Theory of Aging (History and Modern Concepts)"

“…The transfer of the hyperplastic reaction by lymphocytes is possible for any tissue and any process, e.g., isoproterenolinduced hypertrophy of the salivary gland of rodents, functional heart hyperplasia etc., [13][14][15]. It was shown also that signs of bone tissue growth-osteopetrosis, are corrected by transfer of lymphocytes from healthy animals; moreover, parathyroid hormone, which is specific for osteoclasts, produces the effect through T-lymphocytes, which have receptors to this hormone unlike the osteoclasts [16].…”

“…The system of T-cell-regulators is much more complex than the systems of T-and B-effectors of immunity, and moreover, T-cells of the immune system recognize a foreign antigen in а complex with antigens of the major histocompatibility complex.The science of immunology presents thorough studies and detailed descriptions of the so-called "syngenic mixed lymphocyte culture" (sMLC), when T-cells, mainly of the T-helper and T-suppressor type, show a vigorous proliferation in response to the organism's own cells, including nonimmune ones; these are «surplus» cells in classical immunology and they can be removed by antisera without changes in the ordinary immune reactions [13,21,22].…”

The Interstitial Mechanisms of Regulation of Cell Growth and the Role of the Immune System: A New Immune Theory of Aging

“…[22][23][24][25] The transfer of the hyperplastic reaction by lymphocytes is possible for any tissue and any process, e.g., isoproterenol-induced hypertrophy of the salivary gland of rodents, functional heart hyperplasia etc. 3,23,26,27 The regulation of fibroblast proliferation by T-lymphocytes, including the release of fibroblast-specific lymphokines, is well known. It was shown also that signs of bone tissue growth -osteopetrosis, are corrected by transfer of lymphocytes from healthy animals; moreover, parathyroid hormone, which is specific for osteoclasts, produces the effect through T-lymphocytes, which have receptors to this hormone unlike the osteoclasts.…”