Isoproterenol Induced Myocardial Infarction: Protective Role of Natural Products

Upaganlawa, Aman; Gandhi, Hardik; Balaraman, R

doi:10.3923/jpt.2011.1.17

Cited by 109 publications

(71 citation statements)

References 18 publications

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“…CVD is primarily caused by chronic deficiencies of vitamins and other essential nutrients with important properties like coenzymes, cellular energy carriers and free radical scavengers. Many dietary antioxidants and some non-nutrient based antioxidants from plants are increasingly being recognized as possible health promoters in plummeting the risk of CVD [2] .…”

Section: Introductionmentioning

confidence: 99%

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

Upaganlawar

Vaibhav

Balaraman

2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

Upaganlawar

Vaibhav

Balaraman

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Among these, the ischemic heart diseases, Acute Myocardial Infarction (AMI) in particular, is one of the most alarming values (Upaganlawar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Jahromi¹,

Shojaei²,

Farjam³

et al. 2013

American Journal of Immunology

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Acute Myocardial Infarction (AMI) is the combined result of environmental factors and personal predispositions. Many factors play a role in AMI including anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. AntiPhosphatidylserine (PS) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PS antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of acute coronary syndromes. This study was conducted to evaluate whether prevalence of anti-PS antibodies, in patients who had AMI and to analyze their relationship with traditional cardiovascular risk factors. The prevalence of anti-PS IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from two groups were tested to evaluate the presence of IgG and IgM isotypes to anti-PS by ELISA method. The frequencies of positive test for anti-PS IgG were 26.70 and 8.90% among patients and controls respectively with significant difference (p = 0.003). The anti-PS IgM frequencies were 12.20 and 1.10% in patients and the controls, with significant difference (p = 0.005). The findings of this study suggest that anti-PS antibodies seemed to play a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and atherosclerosis in patients with AMI. Further studies with bigger sample size including patients with AMI and healthy people are recommended to explore the exact role of anti-PS antibodies in AMI.

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“…Some investigators reported that isoproterenol produces a number of biochemical and electrophysiological disturbances which ultimately causes disorganization of normal histological structure of the heart tissue 22 . Again, high dose of isoproterenol causes degeneration and necrosis of myocardial fibers, accumulation of inflammatory cells, hyalinization of muscle fibers etc due to increased production of free radicals 17,18 .…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Naz

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

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Background: Cardiotoxicity (CT) can be developed due to prolonged use of higher doses of some drugs, exposure to some chemicals, toxins or infectious agents and also by some disease conditions. Natural plant foods such as peanut (Arachis hypogaea L.) may have free radical scavenging activity, thereby can be used for the prevention and management of heart disease. Objective: To observe the protective effect of peanut (Arachis hypogaea L.) and its combined action with propranolol on histological changes in isoproterenol induced cardiotoxic rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka in 2012. For this purpose, 20 Wistar albino rats, age 85-100 days, weighing 120 to 150g (initial body weight) were included in the peanut treated group. They were sub-divided into CT-ISO-P (Cardiotoxic group with isoproterenol after peanut treatment) and CT-ISO-C (Cardiotoxic group with isoproterenol after combined treatment of peanut and propranolol). Age and weight matched 30 Wistar albino rats without any peanut supplementation were taken and sub-divided into three sub-groups, BC (Baseline control), CT-ISO (Cardiotoxic group with isoproterenol) and CT-ISO-PRO (Cardiotoxic group with isoproterenol after propranolol treatment). Each sub-group consisted of 10 rats. After taking final body weight all the rats were sacrificed on 22 nd day. The heart was removed and preserved in 10% formalin for histological processing. To find out the histopathological changes of heart tissue, histological slides were prepared and were observed under microscope in the Department of Pathology, SSMC. Histological findings were categorized by scoring as mild, moderate and severe histological changes. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Result: In this study, percent change from initial body weight to final body weight was significantly (p<0.01) lower both in CT-ISO-P and CT-ISO-C as compared to that of BC. Again, histological score was significantly (p<0.01) higher in CT-ISO in comparison to that of BC. Moreover, these scores were significantly lower in CT-ISO-PRO (p<0.01), CT-ISO-P (p<0.05) and CT-ISO-C (p<0.05) in comparison to that of CT-ISO. Similarly, this score was significantly (p<0.01) lower in CT-ISO-C when compared to that of CT-ISO-P. Conclusion: The present study revealed that peanut can preserve almost normal histological architecture of heart tissue in isoproterenol induced cardiotoxic rats. However, the combined therapy of peanut with propranolol showed synergistic effect on preventing histological changes in heart tissue.

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Isoproterenol Induced Myocardial Infarction: Protective Role of Natural Products

Cited by 109 publications

References 18 publications

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

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