Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats

Jayachandran, Muthukumaran; Wu, Ziyuan; Ganesan, Kumar; Khalid, Samina; Chung, Su-Ryoung; Xu, Baojun

doi:10.1016/j.cbi.2019.02.017

Cited by 69 publications

(37 citation statements)

References 26 publications

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“…Polyphenols, flavonoids, and food rich-flavonoids also present lipid-lowering properties that could ameliorate lipotoxicity in diabetic kidney disease [241]. Recently, a study performed by Jayachandran et al demonstrated the capacity of isoquecertin to regulate lipid metabolism via AMPK pathway [196]. Besides, quercetin was also able to reduce lipid accumulation in the kidney, individually or in association with allopurinol, a uric acid inhibitor [197,198].…”

Section: Polyphenols Flavonoids and Nutraceuticalsmentioning

confidence: 99%

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Opazo-Ríos

Mas

Marín-Royo

et al. 2020

IJMS

210

147

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Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated with the development of kidney diseases, in particular diabetic nephropathy. Chronic hyperinsulinemia, often seen in type 2 diabetes, plays a crucial role in blood and liver lipid metabolism abnormalities, thus resulting in increased non-esterified fatty acids (NEFA). Excessive lipid accumulation alters cellular homeostasis and activates lipogenic and glycogenic cell-signaling pathways. Recent evidences indicate that both quantity and quality of lipids are involved in renal damage associated to lipotoxicity by activating inflammation, oxidative stress, mitochondrial dysfunction, and cell-death. The pathological effects of lipotoxicity have been observed in renal cells, thus promoting podocyte injury, tubular damage, mesangial proliferation, endothelial activation, and formation of macrophage-derived foam cells. Therefore, this review examines the recent preclinical and clinical research about the potentially harmful effects of lipids in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity.

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Section: Polyphenols Flavonoids and Nutraceuticalsmentioning

confidence: 99%

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Opazo-Ríos

Mas

Marín-Royo

et al. 2020

IJMS

210

147

View full text Add to dashboard Cite

show abstract

“…These ethnopharmacological techniques have been reinforced to yield bioactive compounds that support to improve modern medicine as beneficial tools [67][68][69][70]. Bioactive compounds often contribute a noteworthy function in drug finding by helping as a novel drug of interest and templates for synthetic agents [71][72][73]. Copious investigations have established that natural bioactive compounds have possible antimycobacterial activities [2,60,74,75].…”

Section: Challenges In Diagnosing and Treatment Of Ntm Diseasesmentioning

confidence: 99%

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

2020

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Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.

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“…In this sense, a study performed by Mohammed Yusof demonstrated that Hibiscus sabdariffa (roselle) polyphenol-rich extract, including anthocyanidins, acts as a cardioprotective agent by lowering total cholesterol, triglyceride and LDL and increasing HDL [110]. Likewise, isoquercertin [111] and galangin [112] have been shown to decrease triglycerides, phospholipids and free fatty acids in diabetic rats, whereas scutellarin alleviated dyslipidemia in db/db mice by increasing HDL and reducing triglycerides and total cholesterol [113].…”

Section: Diabetic Macrovascular Complicationsmentioning

confidence: 99%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats

Cited by 69 publications

References 26 publications

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

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