Isoquinoline alkaloids from Broussonetia papyrifera fruits

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT‐A37

“…Cells were plated in a 96‐well plate 24 h before treatment. After that, the compounds were added and the cells were incubated for an additional 48 h. Cytotoxic activity of these compounds was determined by a crystal violet assay as previously described . Results were expressed as the mean value of triplicate determinations and experiments were carried out five times on separate occasions.…”

Stigmalactam from Orophea Enterocarpa Induces Human Cancer Cell Apoptosis Via a Mitochondrial Pathway

“…N-norchelerythrine and dihydrosanguinarine, from Broussonetia papyrifera (L.) Vent. (Moraceae), a traditional Chinese medicinal herb, are cytotoxic to human cervical cancer HeLa and hepatocellular carcinoma BEL-7402 cells (Pang et al, 2014). Camptothecin, a potent alkaloid drug with an anticancer effect, is extracted from the bark and stem of Camptotheca acuminata, which contains the mechanism of action to inhibit topoisomerase I activity (Efferth et al, 2007;Ulukan and Swaan, 2002).…”

“…This leads to further modification of structure-activity relationship to achieve anticancer effect without cytotoxicity to normal cells (Pang et al, 2014).…”

Domino Transformations of Ene/Yne Tethered Salicylaldehyde Derivatives: Pluripotent Platforms for the Construction of High sp3 Content and Privileged Architectures

“…[32] Benzophenanthridinesa re isoquinoline alkaloids possessing intriguing analgesic and anti-inflammatory activities. [33] Owing to their significant biological activities, o-ene/yne tethered benzaldehydes were used for the construction of these scaffolds through [4+ +2] hetero-Diels-Alder reactions. [34] The 2-(cinnamyloxy)benzaldehyde( 45 a)o rN-cinnamyl-N-(2-formylphenyl)-4-methylbenzenesulfonamide (45 b)w ere treated with arylamines 10 using Ru(bpy) 3 (PF 6 ) 2 as the photosensitizer and BF 3 ·Et 2 Oa sa ne ffectiveL ewis acid catalyst.…”