Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury

Zhang, Najuan; Pei, Fei; Wei, Huaying; Zhang, Tongtong; Yang, Chao; Ma, Gang; Yang, Chao

doi:10.1016/j.etp.2009.09.005

Cited by 44 publications

(26 citation statements)

References 36 publications

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“…A number of studies suggested that isorhamnetin can protect endothelial cells from injury caused by oxidized low-density lipoprotein [19], decrease blood pressure [20], and alleviate the damages of ischemia-reperfusion (I/R) to ventricular myocytes [21]. Our laboratory study recently demonstrated that isorhamnetin can prevent H 2 O 2 -induced oxidative injury to H9c2 cardiomyocytes [22].…”

Section: Introductionmentioning

confidence: 97%

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

Sun

Meng

et al. 2013

PLoS ONE

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Doxorubicin (Dox) is an anthracycline antibiotic for cancer therapy with limited usage due to cardiotoxicity. Isorhamnetin is a nature antioxidant with obvious cardiac protective effect. The aim of this study is going to investigate the possible protective effect of isorhamnetin against Dox-induced cardiotoxicity and its underlying mechanisms. In an in vivo investigation, rats were intraperitoneally (i.p.) administered with Dox to duplicate the model of Dox-induced chronic cardiotoxicity. Daily pretreatment with isorhamnetin (5 mg/kg, i.p.) for 7 days was found to reduce Dox-induced myocardial damage significantly, including the decline of cardiac index, decrease in the release of serum cardiac enzymes and amelioration of heart vacuolation. In vitro studies on H9c2 cardiomyocytes, isorhamnetin was effective to reduce Dox-induced cell toxicity. A further mechanism study indicated that isorhamnetin pretreatment can counteract Dox-induced oxidative stress and suppress the activation of mitochondrion apoptotic pathway and mitogen-activated protein kinase pathway. Isorhamnetin also potentiated the anti-cancer activity of Dox in MCF-7, HepG2 and Hep2 cells. These findings indicated that isorhamnetin can be used as an adjuvant therapy for the long-term clinical use of Dox.

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Section: Introductionmentioning

confidence: 97%

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

Sun

Meng

et al. 2013

PLoS ONE

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“…The major individual phenolics identified by HPLC ( Figure 1) were gallic acid, chlorogenic acid, caffeic acid, quercetin-3-O-rutinoside, dicaffeoyltartaric acid, and isorhamnetin (Table 1). The phenolics quercetin-3-O-rutinoside and isorhamnetin (both flavonoids) represented 79% of the total individual phenolics identified, which is important since these two flavonoids are often associated with the decrease of imflammatory and cardiovascular risk and frequently reported as antagonizing agents of oxidation and apoptosis processes (Zhang et al, 2011;Russo, Spagnuolo, Tedesco, Bilotto, & Russo, 2012). Comparing with conventional production (Justesen & Knuthsen, 2001;Tiveron et al, 2012) and other physiological stages (adult and mature plants), the organic baby-leaf watercress presented higher diversity and levels of phytochemicals (1.5 times more), which means that this type of plant material is a good natural source of antioxidants compounds, particularly quercetin-3-O-rutinoside, a potent antioxidant compound.…”

Section: Phytochemicalsmentioning

confidence: 99%

Phytochemical characterization and antioxidant properties of baby-leaf watercress produced under organic production system

Aires

Carvalho

Rosa

et al. 2013

CyTA - Journal of Food

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The aim of this study was to evaluate the phytochemical composition and the antioxidant properties of watercress (Nasturtium officinale R. Br., Brassicaceae) produced under organic production system. Fresh baby-leaf watercress samples were collected from local organic farms. High performance liquid chromatography with diode array detection (HPLC-DAD) and high performance liquid chromatography with diode array detection mass spectrometry (HPLC-MS) were used to assess the phytochemical composition, and spectrophotometric methods were used to assess the antioxidant capacity. Two major classes of healthier secondary plant metabolites were identified: phenolics and glucosinolates. The major phenolics determined were chlorogenic acid, quercetin-3-O-rutinoside, dicaffeoyltartaric acid, and isorhamnetin. The glucosinolates were composed exclusively of gluconasturtiin, the precursor of the anticarcinogenic, and antimicrobial compound 2-phenylethyl isothiocyanate. The extracts of organic young baby-leaf watercress presented high antioxidant capacity and this property was highly related with caffeic acid, quercetin-3-O-rutinoside, isorhamnetin, and glucosnastrutiin. The results achieved showed that baby-leaf watercress can provide high contents of antioxidant compounds at levels even superior to similar adult plant material.Keywords: watercress; baby-leaf samples; organic production; bioactive compounds; phenolic acids; flavonoids; quercetin-3-O-rutinoside; antioxidant activity El objetivo de este estudio fue evaluar la composición fitoquímica y propiedades antioxidantes de berros (Nasturtium officinale R. Br., Brassicaceae) producidos bajo el sistema de producción ecológico. Muestras frescas de hojas tiernas de berros se recolectaron en granjas ecológicas locales. HPLC-DAD y HPLC-MS fueron utilizados para evaluar la composición fitoquímica y métodos espectrofotométricos se utilizaron para evaluar la capacidad antioxidante. Se identificaron dos clases principales de metabolitos secundarios saludables de las plantas, compuestos fenólicos y glucosinolatos. Los principales compuestos fenólicos determinadas fueron: ácido clorogénico, quercetina-3-O-rutinósido, ácido dicafeoil tartárico y isoramnetina. Los glucosinolatos fueron compuestas exclusivamente por gluconasturtina, el precursor del compuesto anti-cancerígenos y antimicrobiana isotiocianato de 2-feniletilo. Los extractos de brotes jóvenes de berros ecológicos presentaron una alta capacidad antioxidante y esta propiedad fue muy relacionadas con el ácido cafeico, la quercetina-3-Orutinósido, isorhamnetina y glucosnastrutiina. Los resultados obtenidos mostraron que los brotes de berro puede proporcionar un alto contenido de compuestos antioxidantes a niveles aún superiores del material similar de la planta adulta. Palabras

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“…Isorhamnetin is an abundant Flavonolaglycone in herbal medicinal plants, such as sea buckthorn (Hippophaerhamnoides L.) and Ginkgo biloba L., which are frequently used inthe prevention and treatment of cardiovascular diseases [14][15] . A number of studies suggested that isorhamnetin can protect endothelial cells from injury caused by oxidized low-densitylipoprotein 16 , decrease blood pressure 17 , and alleviate the damages of ischemiareperfusion (I/R) to ventricular myocytes 18 .…”

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confidence: 99%

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2016

IJPSR

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ABSTRACT:Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease. The present study was designed to investigate the neuroprotective effects of isorhamnetin (IRN) against amyloid beta 25-35 (Aβ 25-35)-induced memory impairment and oxidative damage in rats. Memory task was assessed using Y-arm maze and it revealed the impairment in spatial memory. The IRN treated rats showed improvement in memory task. Aβ 25-35 induced animals also exhibited increase in hydrogen peroxide (H 2 O 2), Monoamine oxidase activity (MAO) and decrease in choline acetyltransferase (ChAT) activity. It also enhanced the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokine, IL-β whereas all these abnormalities were reduced significantly in IRN treated rats showing the neuroprotective effect of IRN against Aβ 25-35 induced Alzheimer's disease (AD). Thus, IRN may be a potential therapeutic agent for Alzheimer's disease.

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Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury

Cited by 44 publications

References 36 publications

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

Phytochemical characterization and antioxidant properties of baby-leaf watercress produced under organic production system

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