Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway

Li, Zhenyu; Shi, Huasong; Li, Yanmei; Wang, Wang; Li, Zhexi; Chen, Biao; Nie, Daibang

doi:10.1016/j.ejphar.2022.174971

Cited by 4 publications

(2 citation statements)

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“…IRN is one of the main active ingredients and is widely used in traditional Chinese medicine. It has anti-inflammatory effects on glial cells, acute kidney injury and other conditions ( YUAN et al, 2009 ; Chen et al, 2010 ; Zheng et al, 2021 ; Li et al, 2022 ). Research on the treatment of lung diseases with IRN has gradually increased.…”

Section: Discussionmentioning

confidence: 99%

“…Previous research on IRN has mainly focused on its anti-inflammatory and antioxidant effects on the cardiovascular, cerebrovascular and central nervous systems (Deng et al, 2021;Zhou et al, 2013). After it was found that it had antiinflammatory and antioxidant effects, the research on IRN was gradually extended to acute renal injury, osteoarthritis and lung injury (Zheng et al, 2021;Li et al, 2022). It was found that IRN can reduce the release of inflammatory mediators in lung tissue and alleviate the disease process of acute lung injury.…”

Section: Introductionmentioning

confidence: 99%

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Mechanism of isorhynchophylline in lipopolysaccharide-induced acute lung injury based on proteomic technology

Li,

Xing,

Qin

et al. 2024

Front. Pharmacol.

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Isorhynchophylline (IRN), a tetracyclic indole alkaloid, has anti-inflammatory and antioxidant activities against cardiovascular diseases and central nervous system disorders. Acute lung injury (ALI) is a manifestation of inflammation concentrated in the lungs and has a high incidence rate and mortality The purpose of this study is to explain the mechanism of IRN in the treatment of acute lung injury and to provide a new scheme for clinical treatment. The experimental mice were divided into three groups: CTRL, LPS, LPS+IRN. The mouse model of ALI was established by inhaling LPS solution through nose. After continuous administration of IRN solution for 7 days, the mice in LPS+IRN group were killed and the lung tissue was collected for detection. Proteomic (Data are available via ProteomeXchange with identifier PXD050432) results showed that 5727 proteins were detected in mouse lung tissues, and 16 proteins were screened out. IRN could reverse the trend of these differential proteins. In addition, IRN can act on integrin αM to reduce neutrophil recruitment and thereby produce anti-inflammatory effects and may suppress neutrophil migration through the leukocyte transendothelial migration pathway. TUNEL and RT-PCR experiments revealed that LPS-induced ALI in mice increases the apoptosis of lung tissues, damage to alveolar epithelial cells and levels of inflammatory factors. Treatment with IRN can repair tissues, improve lung tissue pathology and reduce lung inflammation.

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