A comprehensive study is presented for empirical seismic vulnerability assessment of typical structural types, representative of the building stock of Southern Europe, based on a large set of damage statistics. The observational database was obtained from post-earthquake surveys carried out in the area struck by the September 7, 1999 Athens earthquake. After analysis of the collected observational data, a unifi ed damage database has been created which comprises 180,945 damaged buildings from/after the near-fi eld area of the earthquake. The damaged buildings are classifi ed in specifi c structural types, according to the materials, seismic codes and construction techniques in Southern Europe. The seismic demand is described in terms of both the regional macroseismic intensity and the ratio α g /a o , where α g is the maximum peak ground acceleration (PGA) of the earthquake event and a o is the unique value PGA that characterizes each municipality shown on the Greek hazard map. The relative and cumulative frequencies of the different damage states for each structural type and each intensity level are computed in terms of damage ratio. Damage probability matrices (DPMs) and vulnerability curves are obtained for specifi c structural types. A comparison analysis is fulfi lled between the produced and the existing vulnerability models.