Isosexual precocious puberty associated with multilocular arachnoid cysts at the cranial base

Okamoto, Kazuo; Nakasu, Yoko; Sato, Manabu; Handa, Jyoji

doi:10.1007/bf01665118

Cited by 12 publications

(4 citation statements)

References 9 publications

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“…About 16 cases of central precocious puberty have been reported in patients with suprasellar arachnoid cyst [3±5, 10,12,13,16,18,21], with regression of the pubertal development after derivation of the cyst in six of them [4,18,21]. Menstruation may be the ®rst sign in girls, as in two of our six patients.…”

Section: Discussionmentioning

confidence: 72%

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Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst

Adan¹,

Bussières

Dinand³

et al. 2000

European Journal of Pediatrics

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A suprasellar arachnoid cyst may cause disorders of growth, puberty and hypothalamic-pituitary function, due to the proximity of the cyst to the hypothalamic-pituitary area. A total of 30 patients (17 boys) with cyst diagnosed at 4.3 1 years were routinely evaluated at 5.4 1 years; 24 of them had one or multiple cyst derivations. Some 23 cases had an abnormal height, weight or puberty: short (<)2SD, 5 cases) or tall (>2SD, 10 cases) stature, overweight (body mass index, BMI, >2SD, 6 cases), central precocious puberty (10 cases) and/or no progression of pubertal development (3 cases). The growth hormone (GH) peaks after pharmacological stimulation test were low (<10 lg/l) in 16 patients, con®rmed by a second evaluation in 8/11 of them. The plasma free thyroxine was low in ®ve patients, prolactin was high in two and the cortisol and concomitant plasma and urinary osmolalities were normal. BMI was correlated negatively with the GH peaks (r )0.37, P < 0.01) and positively with the plasma leptin concentrations (r 0.55, P < 0.01). The plasma fasting insulin concentrations were also correlated negatively with the GH peaks (r )0.55, P < 0.02) and positively with the plasma insulin-like growth factor I concentrations (r 0.64, P < 0.002). The adult height (12 cases) was at 4SD in 1 and <)2SD in 4 patients, two of whom had precocious puberty untreated with gonadotropin releasing hormone (GnRH) analogue, and two had untreated GH de®ciency. The adult height of those treated was normal. One girl had primary amenorrhoea and two boys had low plasma testosterone, despite a normal gonadotropin response to a GnRH test. Conclusion Suprasellar arachnoid cysts may cause de®ciencies of growth hormone and thyrotropin, stimulation of the hypothalamic-pituitary-gonadal axis, tall stature and/or overweight. These last two disorders may be due to hyperinsulinism, itself due to suprasellar arachnoid cyst.

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Section: Discussionmentioning

confidence: 72%

“…A suprasellar arachnoid cyst may cause central precocious puberty [3±5, 10,12,13,16,18,21], amenorrhoea, short stature and/or obesity [12]. These disorders are all due to the proximity of the cyst to the hypothalamicpituitary area, but how they are caused is unknown.…”

Section: Introductionmentioning

confidence: 98%

Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst

Adan¹,

Bussières

Dinand³

et al. 2000

European Journal of Pediatrics

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“…Various treatment modalities have been described for symptomatic supratentorial arachnoid cysts, including endoscopic fenestration [12], craniotomy and excision of the cyst lining (marsupialization) with optional ventriculoperitoneal shunting [13], a cysto-peritoneal shunt [6] and a percutaneous ventriculocystostomy [14]. …”

Section: Discussionmentioning

confidence: 99%

Sylvian Cistern Arachnoid Cyst - A Rare Cause of Precocious Puberty

Upadhyaya¹,

Nair²,

Kumar³

et al. 2013

Pediatr Neurosurg

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Precocious puberty still remains an elusive diagnosis in the majority of patients. Infrequently, lesions of the central nervous system are associated with sexual precocity. Depending on their location, these cysts may affect many systems, however, there is little information concerning their involvement in endocrinological disorders. We report a case of a sylvian cistern arachnoid cyst presenting with precocious puberty in a 3-year-old girl. The child recovered following a cystoperitoneal shunt. The mass effect of the arachnoid cyst upon the hypothalamus was, at least in part, responsible for the development of precocious puberty. To the best of our knowledge, this is the 1st case of a sylvian cistern arachnoid cyst presenting with precocious puberty. The role of surgical decompression of the cyst is also discussed.

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“…Vision disorder and neurologic disorder occur in 25-85% of patients with SAC, while various endocrine disorders, including precocious puberty, occasionally with fulminant course (pubertas fulminans), occur in 10-40% of children with SAC [10,[14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Social alienation caused by precocious puberty and hypothalamic obesity in patients with suprasellar arachnoid cysts - Case studies and literature review of a rare but significant disorder

Hałabuda¹,

Franczak-Young²,

Klasa³

et al. 2020

J Syst Integr Neurosci

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Suprasellar arachnoid cysts (SAC), due to their location, are a separate group, regarding clinical symptoms and therapeutic approach, compared to AC in other locations. For this reason they are more similar to other benign suprasellar lesions. SACs are most often diagnosed in children. Symptoms of SAC depend on the age in which they occurred. The treatment needs the engagement of consultant doctors from many fields: neurosurgery, neurology, ophthalmology, endocrinology and radiology and should be also supported by psychologists.

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Isosexual precocious puberty associated with multilocular arachnoid cysts at the cranial base

Cited by 12 publications

References 9 publications

Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst

Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst

Sylvian Cistern Arachnoid Cyst - A Rare Cause of Precocious Puberty

Social alienation caused by precocious puberty and hypothalamic obesity in patients with suprasellar arachnoid cysts - Case studies and literature review of a rare but significant disorder

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