Isosteviol improves cardiac function and promotes angiogenesis after myocardial infarction in rats

Liu, Fei; Song, Laisi; Lu, Zhiqiang; Sun, Tingwei; Lun, Jingwen; Zhou, Chengbin; Sun, Xiouou; Tan, Wen; Zhao, Huan

doi:10.1007/s00441-021-03559-9

Cited by 4 publications

(1 citation statement)

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“…Cardiac function was measured in rats anesthetized with isoflurane, briefly, the catheter was inserted into the jugular vein, and guided into the right ventricle, then hemodynamic data were measured, include RVSP (Right Ventricular Systolic Pressure), max dp/dt and min dp/dt [11,12], heart rate (HR), right ventricular end-diastolic pressure (RVEDP), pulmonary artery systolic pressure, mean pulmonary artery pressure. The right ventricle and the left ventricle plus interventricular septum were separated and weighed respectively to calculate RV/(LV+S) as right ventricular hypertrophy index.…”

Section: Measurement Of Cardiac Functionmentioning

confidence: 99%

Hypoxia-Induced Cardiomyocyte Apoptosis Exacerbates Cardiomyocyte Hypertrophy and Myocardial Injury through p38 MAPK Pathway in SD Rats

Li¹,

Pu²,

Xu³

et al. 2023

Preprint

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Right ventricular remodeling and its function are closely related to the symptom severity and survival of hypoxia pulmonary hypertension, but molecular mechanisms of cardiomyocyte hypertrophy and myocardial injury remain unclear. It evaluated the cardiac function (by right cardiac catheterization to measure right ventricular systolic pressure and mean pulmonary artery pressure), myocardial tissue morphology（Haematoxylin and Eosin）, myocardial hypertrophy (Wheat Germ Agglutinin Staining), then RNA sequencing was applied to explore the mechanism, which results were verified by western blot in final. Hypoxia developed pulmonary hypertension, right ventricular diastolic and systolic functions were enhanced in rats, such as the mean pulmonary artery pressure, systolic pressure of pulmonary artery, the max pressure of right ventricular, the mean right ventricular pressure, and the heart rate was significantly higher than that in control. We found that Hif-1 signaling pathway and p38-MAPK signaling pathway have been activated by hypoxia, and cardiomyocyte apoptosis also aggravated in the right ventricular, which might be one cause of cardiomyocyte hypertrophy and myocardial injury, and targeted intervention might be one potential prevention for cardiomyocyte hypertrophy and myocardial injury induced by hypoxia.

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Section: Measurement Of Cardiac Functionmentioning

confidence: 99%