We theoretically investigate the thermodynamic stability of a normal-state Bose-Fermi mixture, with a tunable Bose-Fermi pairing interaction −U BF < 0 associated with a hetero-nuclear Feshbach resonance, as well as a weak repulsive Bose-Bose interaction U BB ≥ 0. Including strong heteropairing fluctuations associated with the former interaction within the self-consistent T -matrix approximation, as well as the latter within the mean-field level, we calculate the compressibility matrix, to assess the stability of this system against density fluctuations. In the weak-and the intermediate-coupling regime with respect −U BF , we show that an effective attractive interaction between bosons mediated by density fluctuations in the Fermi component makes the system unstable below a certain temperature T clp (leading to density collapse). When U BB = 0, T clp is always higher than the Bose-Einstein condensation (BEC) temperature T c . When U BB > 0, the density collapse is suppressed, and the BEC transition becomes possible. It is also suppressed by the formation of tightly bound Bose-Fermi molecules when the hetero-pairing interaction −U BF is strong; however, since the system may be viewed as a molecular Fermi gas in this case, the BEC transition does not also occur. Since quantum gases involving Bose atoms are known to be sensitive to inter-particle correlations, our results would be useful for the study of many-body properties of a Bose-Fermi mixture in a stable manner, without facing the unwanted density collapse.Recently, Bose-Fermi mixtures have attracted much attention in cold atom physics [1][2][3][4][5][6][7]. Since one can tune the strength of a Bose-Fermi pairing interaction by adjusting the threshold energy of a hetero-nuclear Feshbach resonance[8], strong-coupling properties of this gas mixture have been studied [9][10][11][12][13]. In addition, tuning of an effective Bose-Bose (Fermi-Fermi) interaction mediated by Fermi (Bose) component has also been discussed [14][15][16][17]. As an interesting possibility, a non-s-wave Fermi superfluid induced by such a boson-mediated pairing interaction has recently been proposed [18][19][20].Bose-Fermi mixtures have also been discussed in other research fields, e.g., 3 He-4 He mixture [21][22][23], as well as a high-density QCD matter[24] (where the system is regarded as a mixture of bound di-quarks (bosons) and unpaired quarks (fermions)). In condensed matter physics, as a possible route to reach high-temperature superconductivity, a nano-device consisting of a n-doped semiconductor (electron gas) immersed in an exciton-polariton BEC (bosons) has theoretically been proposed [25][26][27]. Since a Bose-Fermi mixture in cold atom physics is simple and highly tunable, this dilute gas system is expected as a useful quantum simulator [28] for the study of these more complicated many-body quantum systems.In considering a Bose-Fermi mixture with a hetero-nuclear Feshbach resonance, besides strong-coupling effects caused by a Feshbach-induced tunable interaction, thermodynamic s...