“…Heterocyclic skeletons, which have sulfur and nitrogen as core elements, are the subject of long-standing interest due to their widespread presence in different pharmaceuticals, bioactive compounds, and functional materials . In this context, isothiazolone is a significant class of N , S -containing heterocycle, which possesses remarkable biological activities, including antimicrobial, anti-inflammatory, antifouling, and antitumor . They are prevalent in various biocides, agrochemicals, preservatives, household cleaning products, and personal care products .…”