Isothiocyanates as derivatization reagents in the determination of 1, 1-dimethylhydrazine by gas chromatography coupled with mass spectrometry

Abstract

Alkyl isothiocyanates were proposed for the determination of 1,1 dimethylhydrazine (DMH) in the form of 4 alkyl 1,1 dimethylthiosemicarbazides by gas chromatography coupled with mass spectrometry (GC MS). 4 Alkyl 1,1 dimethylthiosemicarbazides are selectively formed under mild conditions in the absence of catalysts. During the chromatography, these thiosemi carbazides are efficiently resolved from excess of alkyl isothiocyanates. A possibility of identifi cation of DMH derivatives on the basis of the chromatographic retention parameters and fragmentation data under electron ionization conditions was demonstrated.