Isothiocyanates: happy-go-lucky reagents in organic synthesis

Abstract

: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic...

Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries

“…Isothiocyanates (ITCs), featuring the NCS moiety, harbor both electrophilic and nucleophilic sites contributing to its diverse reactivity. 7 Therefore, ITCs possess the potential as a divergent synthetic intermediate in DEL. Although ITCs have found use as reagents in DEL synthesis, 8 the isolation of this versatile intermediate on DNA and its potential for divergent DEL synthesis remain unexplored.…”