Isotope-coded derivatization based LC/ESI-MS/MS methods using a pair of novel reagents for quantification of hydroxycinnamic acids and hydroxybenzoic acids in fermented brown rice product

Ogawa, Shoujiro; Takafuji, Kiriko; Tsubuku, Sumi; Horie, Yukiko; Ikegawa, Shigeo; Higashi, Tatsuya

doi:10.1016/j.jpba.2017.04.035

Cited by 18 publications

(12 citation statements)

References 32 publications

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“…Dietary fibers are partially digested, and free vitamins and phenolic compounds have increased in FBRA [38,39]. Increase of polyamines, phenolic acids, and ergothioneine have been demonstrated by LC/ESI-MS/MS [35,40,41]. Polyamines such as putrescine and spermidine are essential for cell growth, proliferation and tissue regeneration, but the expression of polyamine synthetic enzymes have been declining with aging [35].…”

Section: Biologically Active Components In Aspergillus Oryzae-mediated Fermentation Products Of Brown Ricementioning

confidence: 99%

Fermented Brown Rice as a Functional Food

Kataoka¹

2022

Integrative Advances in Rice Research

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Brown rice, especially in a part of rice bran, contains many kinds of nutrients and biologically active components such as plant polyphenols and phytic acid, but is hard to eat. “Brown rice and rice bran fermented with Aspergillus oryzae (FBRA)” is a processed food that is easier for daily intake, commercially available, and rich in eating experience. During the fermentation process, dietary fibers is partially digested, and free vitamins and phenolic compounds have increased. These fermentation products are utilized for quality control to manage FBRA production. Recently, plant-derived polyphenols have shown anti-oxidative activity and biological function in various disease models. We and other research groups used raw powder FBRA to examine its biological activity through pathological and/or molecular biological analysis. Dietary administration of FBRA showed anti-tumorigenic effects in chemically induced tumors in rodents. Anti-inflammatory effects have been observed in DSS-induced colitis in rat and inflammation-mediated rodent tumor models. I will give an outline of the characteristic of FBRA, and then introduce our recently published work about “Preventive effect of FBRA on spontaneous type 1 diabetes in NOD female mice”, including how to estimate the in vivo effect of dietary FBRA, its possible mechanisms and the limit of this study.

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Section: Biologically Active Components In Aspergillus Oryzae-mediated Fermentation Products Of Brown Ricementioning

confidence: 99%

Fermented Brown Rice as a Functional Food

Kataoka¹

2022

Integrative Advances in Rice Research

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“…2 H 3 ‐ADB was used for the derivatization of standards of known concentration to be used as the IS. The ADB derivatization enhanced the sensitivity, specificity, and precision of the assay (Ogawa et al, ). In the same context, three cholamine labeling reagents ( 2 H 0 ‐, 2 H 3 ‐, and 2 H 9 ‐cholamine) were developed for quantification of 12 fatty acids in a cage and cage‐free chicken egg.…”

Section: Isotope‐coded Derivatization Reagents For Lc–ms Analysismentioning

confidence: 99%

Current trends in isotope‐coded derivatization liquid chromatographic‐mass spectrometric analyses with special emphasis on their biomedical application

El-Maghrabey

Kishikawa

Kuroda

2020

Biomedical Chromatography

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Currently, LC–MS has various applications in different areas such as metabolomics, pharmacokinetics, and pathological studies. Yet, matrix effects resulting from co‐existing constituents remain a major problem for LC–MS [or LC–tandem mass spectrometry (LC–MS/MS)]. Moreover, technical problems and instrumental drifts may lead to ion abundance variance. Thus, an internal standard (IS) is required to guarantee the accuracy and precision of the method. Because of their limited number, isotope‐coded derivatization (ICD) has been recently introduced to overcome this problem. For ICD, a stable heavy isotope‐coded moiety is used for labeling the standard or the control sample and the formed products can act as ISs. A light form of the reagent is used for labeling the sample. Then, both are mixed and analyzed by LC–MS(/MS). This strategy permits the identification of different unknown analytes including potential metabolites and disease biomarkers. All these attributes lead to persistent growth in the applications of ICD LC–MS(/MS) in various biomedical branches. In this article we review the ICD methods published in the last eight years for biomedical applications as well as briefly summarize other applications for environmental and food analyses as some of their used ICD reagents were further applied for analyzing biological specimens or have the potential for that.

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“…Basic composition of FBRA and its manufacturing process are shown previously [3,4]. It is already known that FBRA has fermentationinduced increase of antioxidant phytochemicals [5,6] and acts as a potent free radical scavenger [7]. Among the antioxidant phytochemicals contained in FBRA, polyamines, especially spermidine is known to play a central role in cell proliferation and growth [6].…”

Section: Minireview Minireviewmentioning

confidence: 99%

Fermented Brown Rice and Rice Bran with Aspergillus Oryzae as A New Promising Agent for Cancer Prevention

Mori

2019

AJBSR

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Isotope-coded derivatization based LC/ESI-MS/MS methods using a pair of novel reagents for quantification of hydroxycinnamic acids and hydroxybenzoic acids in fermented brown rice product

Cited by 18 publications

References 32 publications

Fermented Brown Rice as a Functional Food

Fermented Brown Rice as a Functional Food

Current trends in isotope‐coded derivatization liquid chromatographic‐mass spectrometric analyses with special emphasis on their biomedical application

Fermented Brown Rice and Rice Bran with Aspergillus Oryzae as A New Promising Agent for Cancer Prevention

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