Isotope effects on radical pair performance in cryptochrome: A new hypothesis for the evolution of animal migration

Abstract

Mechanisms occurring at the atomic level are now known to drive processes essential for life, as revealed by quantum effects on biochemical reactions. Some macroscopic characteristics of organisms may thus show an atomic imprint, which may be transferred across organisms and affect their evolution. This possibility is considered here for the first time, with the aim of elucidating the appearance of an animal innovation with an unclear evolutionary origin: migratory behaviour. This trait may be mediated by a radical pair (RP) mechanism in the retinal flavoprotein cryptochrome, providing essential magnetic orientation for migration. Isotopes may affect the performance of quantum processes through their nuclear spin. Here, we consider a simple model and then apply the standard open quantum system approach to the spin dynamics of cryptochrome RP. We changed the spin quantum number (I) and g‐factor of hydrogen and nitrogen isotopes to investigate their effect on RP's yield and magnetic sensitivity. Strong differences arose between isotopes with I = 1 and I = 1/2 in their contribution to cryptochrome magnetic sensitivity, particularly regarding Earth's magnetic field strengths (25–65 µT). In most cases, isotopic substitution improved RP's magnetic sensitivity. Migratory behaviour may thus have been favoured in animals with certain isotopic compositions of cryptochrome.

On the optimality of the radical-pair quantum compass

“…Instead, it is plausible that cryptochrome evolved from a common ancestor with photolyases, developing magnetic field sensitivity in an already complex biological setting [44-46, 82, 83], for which numerous hyperfine couplings and EED interactions would be relevant. Previously, in the context of magnetoreception, we have considered structure-function relationships by exploring the optimal relative orientation of radicals in cryptochrome as a feature that may have undergone evolutionary adaptation [61], and the relation to quantum coherence [60], isotopic composition has also been considered as a property that may have been adapted through evolution [84,85]. Separately, in the context of the quantum biology of photosynthesis, studies have also investigated structure-function relationships [86][87][88][89], Fisher-information-based multiparameter sensitivity analysis [90], and reconstructing ancestors in the evolutionary chain [91], considering the effects of potential evolutionary adaptations.…”

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