Isotopic changes during the synthesis of amphetamines

Carter, James F.; Titterton, Emma L.; Grant, Helen; Sleeman, Richard

doi:10.1039/b207775b

Cited by 38 publications

(38 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, it was reported that the d 15 N values of MA synthesized by reductive amination showed large interbatch variation and did not depend on those of methylamine, the only source of nitrogen [7]. These results suggest that differences of the d 13 C values and d 15 N values between the samples originated from differences in raw material batches and synthetic batches, respectively.…”

Section: Irmscontrasting

confidence: 58%

“…In a previous study [7], no isotopic fractionation for d 13 C values was reported for product MA when P2P was almost completely reacted to MA by reductive amination. In contrast, it was reported that the d 15 N values of MA synthesized by reductive amination showed large interbatch variation and did not depend on those of methylamine, the only source of nitrogen [7].…”

Section: Irmsmentioning

confidence: 86%

“…Recently, stable isotope ratio mass spectrometry (IRMS) has been increasingly used in analysis of MA and its precursors to obtain sample-linking information, especially in cases where conventional drug profiling may fail [7][8][9][10][11][12][13]. The isotopic compositions of synthetic substances depend on isotopic variations in the raw materials and isotopic fractionation during the synthetic process.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Profiling of seized methamphetamine putatively synthesized by reductive amination of 1-phenyl-2-propanone

et al. 2011

View full text Add to dashboard Cite

We report a case of seized methamphetamine (MA) samples showing unique drug profiles. Conventional drug profiling such as impurity profiling and chiral analysis as well as stable isotope ratio mass spectrometry (IRMS) was performed on seven MA-HCl samples. The results of impurity profiling suggested that the samples were synthesized by reductive amination. The high enantiomeric purities of the samples suggested that the samples were optically resolved. The d 13 C and d 15 N values gave different grouping patterns from conventional drug profiling. This is the first case report of the use of IRMS with seized MA samples presumptively synthesized by reductive amination.

show abstract

Section: Irmscontrasting

confidence: 58%

Section: Irmsmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Profiling of seized methamphetamine putatively synthesized by reductive amination of 1-phenyl-2-propanone

et al. 2011

View full text Add to dashboard Cite

show abstract

“…As a synthetic drug, the isotopic compositions of an ATS refl ect those of the starting materials, and are also affected by reaction conditions [17][18][19]. According to de Korompay et al [20], the isotopic "signature" might be characteristic of a specifi c batch of MDMA; in their report, multivariate isotopic composition graphs showed clustering of the batches.…”

Section: Introductionmentioning

confidence: 95%

Seized methamphetamine samples with unique profiles of stable nitrogen isotopic composition documented by stable isotope ratio mass spectrometry

et al. 2010

View full text Add to dashboard Cite

“…separation into two groups). Carter et al [10] also investigated isotopic fractionation of amphetamines during synthesis. First, they attempted to identify sources of 13C and 15N observed in illicit amphetamines by investigating the synthesis of methamphetamine.…”

Section: Irms Of Illicit Drugsmentioning

confidence: 99%

Recent Advances in the Application of Stable Isotope Ratio Analysis in Forensic Chemistry

Daéid¹,

Buchanan²,

Savage³

et al. 2010

Aust. J. Chem.

View full text Add to dashboard Cite

This version is available at https://strathprints.strath.ac.uk/27574/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the This review paper updates the previous literature in relation to the continued and developing use of stable isotope ratio analysis in samples which are relevant to forensic science. Recent advances in the analysis of drug samples, explosive materials, and samples derived from human and animal samples are discussed. The paper also aims to put the use of isotope ratio mass spectrometry into a forensic context and discuss its evidential potential.

show abstract

Isotopic changes during the synthesis of amphetamines

Cited by 38 publications

References 5 publications

Profiling of seized methamphetamine putatively synthesized by reductive amination of 1-phenyl-2-propanone

Profiling of seized methamphetamine putatively synthesized by reductive amination of 1-phenyl-2-propanone

Seized methamphetamine samples with unique profiles of stable nitrogen isotopic composition documented by stable isotope ratio mass spectrometry

Recent Advances in the Application of Stable Isotope Ratio Analysis in Forensic Chemistry

Contact Info

Product

Resources

About