We construct a number of topologically trivial but smoothly non-trivial families of embeddings of
3
3
-manifolds in
4
4
-manifolds. These include embeddings of homology spheres in
S
4
S^4
that are not isotopic but have diffeomorphic complements, and families (parameterized by high-dimensional spheres) of embeddings of any
3
3
-manifold that embeds in a blown-up
K
3
K3
surface. In each case, the families are constructed so as to be topologically trivial in an appropriate sense. We also illustrate a general technique for converting a non-trivial family of embeddings into a non-trivial family of submanifolds.