Isotretinoin in the Treatment of Granuloma Annulare

Looney, Melissa; Smith, Kelly M.

doi:10.1345/aph.1d312

Cited by 19 publications

(12 citation statements)

References 16 publications

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“…The inflammatory cell infiltrate seen in GA is comprised of T lymphocytes and macrophages . This idiopathic reaction is believed to be a type‐IV hypersensitivity response to an unidentified antigen …”

Section: Introductionmentioning

confidence: 99%

“…7 This idiopathic reaction is believed to be a type-IV hypersensitivity response to an unidentified antigen. 1,3,8,9 Possible relationships have been reported between GA and diabetes mellitus, thyroid diseases, lipid metabolic disorders, lymphoma and other malignant diseases, insect bites, acquired immunodeficiency syndrome and other viral infections. 10 The familial occurrence of GA appears to be rare, and only a few cases have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of generalized granuloma annulare – a systematic review

Lukács

Schliemann

Elsner

2015

Acad Dermatol Venereol

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Granuloma annulare (GA) is a benign inflammatory skin disease. Localized GA is likely to resolve spontaneously, while generalized GA (GGA) is rare and may persist for decades. GGA usually is resistant to a variety of therapeutic modalities and takes a chronic course. The objective of this study was to summarize all reported treatments of generalized granuloma annulare. This is a systematic review based on MEDLINE, Embase and Cochrane Central Register search of articles in English and German and a manual search, between 1980 and 2013, to summarize the treatment of generalized granuloma annulare. Most medical literature on treatment of GGA is limited to individual case reports and small series of patients treated without a control group. Randomized controlled clinical studies are missing. Multiple treatment modalities for GGA were reported including topical and systemic steroids, PUVA, isotretinoin, dapsone, pentoxifylline, hydroxychloroquine, cyclosporine, IFN-γ, potassium iodide, nicotinamide, niacinamide, salicylic acid, dipyridamole, PDT, fumaric acid ester, etanercept, infliximab, adalimumab. While there are numerous case reports of successful treatments in the literature including surgical, medical and phototherapy options, well-designed, randomized, controlled clinical trials are required for an evidence-based treatment of GGA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment of generalized granuloma annulare – a systematic review

Lukács

Schliemann

Elsner

2015

Acad Dermatol Venereol

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“…Several reports detail the successful use of isotretinoin 0.5-1 mg/kg/day, primarily in the disseminated form of the disease. Temporary remission of disseminated granuloma annulare under oral isotretinoin therapy [134].…”

Section: Disseminated Granuloma Annularementioning

confidence: 99%

Untitled

2012

Our Dermatol Online

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“…These cases clearly represent a major therapeutic challenge and many patients remain troubled by the appearance. The visible and unsightly nature of this skin condition has led to the proposal of a variety of topical and/or systemic treatment methods [5][6][7][8][9][10][11][12][13][14][15] (Table 1)-all with varying degrees of success and each with its own treatment-associated morbidity.…”

Section: Introductionmentioning

confidence: 99%