Isotretinoin systemic therapy and the shadow cast upon dermatology's downtrodden hero

Lowenstein, Elie B.; Lowenstein, Eve J.

doi:10.1016/j.clindermatol.2011.08.026

Cited by 35 publications

(29 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is compatible with the previous studies, which report the most common side effect of OIT as dry lips and cheilitis. (Brzezinski et al, 2017;Charakida et al, 2004;Lowenstein & Lowenstein, 2011;McLane, 2001;Rademaker, 2010. ) Other common side effects include dry nasal membranes up to two-thirds of patients during treatment (Skroza et al, 2018) that can contribute to epistaxis which is known among only 1.2% of the patients in our study.…”

Section: Resultsmentioning

confidence: 99%

“…However, the association between isotretinoin and atypical wound healing remains controversial, there is no data that OIT improves acne scarring. Conversely, OIT is indicated for severe scarring acne (Lowenstein & Lowenstein, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…Isotretinoin has been prescribed to many patients worldwide since its introduction in 1982 (Lowenstein & Lowenstein, ), and its side effects are well described since then. In our study, 76.3% of the patients had heard about the OIT and (69.7%) of them knew about the side effects.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Perceptions about oral isotretinoin treatment

Ayanoğlu

Demirdağ

Yalıcı-Armağan

et al. 2019

Dermatologic Therapy

View full text Add to dashboard Cite

There are some studies on the knowledge, beliefs, and perceptions of patients about acne vulgaris, however, there is no sufficient data on patients' beliefs about oral isotretinoin treatment (OIT). The aim of this study was to assess the knowledge, beliefs, and perceptions of the patients with acne vulgaris about the therapy of OIT and its side effects. A total of 214 patients with acne vulgaris in our outpatient clinic were included. Patients who were planned to treat with OIT were asked whether they had information about the treatment and its side effects. It was noted whether the patients accepted treatment after being informed both verbally and written about the OIT details. The study consisted of 133 female and 81 male aged 12–57 years. Most of the patients (78%) stated that they had heard of OIT. The most common source of the information on isotretinoin therapy was friends (57.6%). The dryness was the best‐known side effect. While 86.4% of patients (n: 185) accepted OIT, the group (14.4%) stated that “I have knowledge about side effects.” And refused to use the treatment. Most of the patients agreed to the treatment after explanation of dermatologist. Patients may be educated and informed via reliable medical sources to prevent bias and improve compliance to the treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Perceptions about oral isotretinoin treatment

Ayanoğlu

Demirdağ

Yalıcı-Armağan

et al. 2019

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Cheilitis is often listed as the most significant mucocutaneous adverse reaction. [1][2][3] Other ones such as xerodermia, facial erythema, pruritis, hair thinning, brittle nails, and epistaxis are to name but a few. By increasing epidermal turn-over and thinning the stratum corneum, retinoids, including isotretinoin, may rarely be associated with photosensitivity.…”

Section: Case Reportmentioning

confidence: 99%

Isotretinoin-induced Facial Hyperpigmentation: Idiosyncratic Reaction?

Halawi¹,

Abbas²

2015

JDRT

View full text Add to dashboard Cite

Isotretinoin is notorious for having a myriad of mucocutaneous side effects including cheilitis, xerodermia, facial erythema, pruritis, hair thinning, and brittle nails, among others. Although photosensitivity is considered to be one of the side effects of oral isotretinoin therapy, cutaneous hyperpigmentation has not, to the best of our knowledge, yet been reported as a side effect. This report presents a case of striking facial hyperpigmentation in a patient on oral isotretinoin.

show abstract

“…They fear that the main consequence of this program may be a reduction of isotretinoin prescriptions that would disadvantage patients, notably those who suffer from the severest form of acne that threatens their quality of life [397]. Finally, the side effects of isotretinoin on pregnancy and the controversies on affective disorders that have restricted its legal prescription and possibly increased illegal purchase over the Internet [398] may transform a revolutionary actor of the acne management into a ‘downtrodden hero' [399]. …”

Section: From Vitamin a To Isotretinoin: Innovative Views On Acne Patmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

View full text Add to dashboard Cite

From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

show abstract

Isotretinoin systemic therapy and the shadow cast upon dermatology's downtrodden hero

Cited by 35 publications

References 133 publications

Perceptions about oral isotretinoin treatment

Perceptions about oral isotretinoin treatment

Isotretinoin-induced Facial Hyperpigmentation: Idiosyncratic Reaction?

Acne Pathogenesis: History of Concepts

Contact Info

Product

Resources

About