Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population

Matsunaga, Hidenori; Tanaka, Susumu; Fukumori, Akio; Tomonaga, Keizō; Ikuta, Kazuyoshi; Amino, Nobuyuki; Takeda, Masatoshi

doi:10.1016/j.jcv.2008.07.011

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…Third, the pathogenesis and symptoms of BDV infection in humans would be different from the infection in animals. Recently, Matsunage et al50 have suggested that human infection of BDV would be asymptomatic and non-pathogenic.…”

Section: Discussionmentioning

confidence: 99%

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Lee

Tae

Song

et al. 2009

Psychiatry Investig

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ObjectiveBorna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea.MethodsWe recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs).ResultsNeither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups.ConclusionOur results suggest that BDV might not be associated with psychiatric patients in Korea.

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Section: Discussionmentioning

confidence: 99%

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Lee

Tae

Song

et al. 2009

Psychiatry Investig

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“…All the patients examined for anti-bornavirus antibodies were those visiting the Department of Psychiatry, Osaka General Medical Center. The IgG, IgM and IgA titers against two bornavirus antigens, nucleoprotein and phosphoprotein, were assayed by radioligand assay as previously described (8,9). Blood samples were stored at 4°C after sampling, and the sera were divided into several tubes A c c e p t e d M a n u s c r i p t and stored at -80°C on the day of sampling.…”

Section: Methodsmentioning

confidence: 99%

“…Specifically, we detected either anti-bornavirus IgG, IgM, or IgA in approximately 20% of both Japanese psychiatric and control subjects (9). The positive rates were 3.5% in both groups if only samples with high titers were selected.…”

Section: Accepted Manuscript Introductionmentioning

confidence: 91%

Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin

et al. 2018

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A c c e p t e d M a n u s c r i p t While we had previously detected anti-bornavirus antibodies via radioligand assay in psychiatric patients, we had not examined the viral pathogenicity in these individuals.Herein, we present two psychiatric patients who were seropositive for bornavirus and whose treatment-resistant symptoms improved by oral administration of ribavirin, a broad-spectrum antiviral agent. Cerebrospinal fluid analysis indicated that the ribavirin affected the central nervous system of these patients. Ribavirin ameliorated intermittent involuntary head shaking, which is reminiscent of a symptom observed in bornavirus-infected animals. Using radioligand assays to examine the serial sera of these patients, we found a relationship between the titers of anti-bornavirus antibodies and the change in the patients' symptoms. Our findings suggest there is a relationship between bornavirus and human symptoms and that ribavirin may be useful in suppressing chronic bornavirus infection in some neuropsychiatric patients. However, the possibility remains that some other known or unknown virus other than bornavirus, which is sensitive to ribavirin, may have caused the symptoms. Additional evidence that directly indicates the causative relationship between bornavirus and human symptoms is needed before establishing the pathogenesis and treatment for human bornavirus infection. .

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“…Для серологічної діагностики з метою виявлення специфічних антитіл до борнавірусів чи їх антигенів у сироватці крові як у тварин, так і людини найчастіше використовують ІФА (Amsterdam et al, 1985;Rott et al, 1985Rott et al, , 2001Waltrip et al, 1995;Bode et al, 1996;Carbone, 2001;Hornig et al, 2012), імуноблотинг (Iwahashi et al, 1997;Carbone, 2001), вестернблот (Waltrip et al, 1995;Flower et al, 2008;Zhang et al, 2014), визначення концентрації циркулюючих імунних комплексів до ВХБ (Bode and Ludwig, 2003;Donfrancesco et al, 2008;Scholbach and Bode, 2008;Mazaheri-Tehrani et al, 2014;Zaliunaite et al, 2016), РЕМА (ELISA) (Carbone, 2001;Zhang et al, 2014), радіоімунний аналіз (Matsunaga et al, 2008).…”

Section: виявлення борнавірусів у біологічному матеріаліunclassified

“…Інші дослідження, проведені в Японії, стосувалися вивчення зразків сироватки крові 304 пацієнтів психіатричних клінік з різними розладами та 378 зразків від здорових донорів на предмет виявлення в них специфічних імуноглобулінів IgM та IgG до ВХБ за допомогою радіоімунного аналізу (Matsunaga et al, 2008). Специфічні антитіла (IgG) до ВХБ, виявлені в обох групах дослідження, були нижче середнього рівня та достовірно не відрізнялися між собою, а ось вміст IgM не зменшувався тривалий час.…”

Section: значення борнавірусів у патології людиниunclassified

Borna disease virus and its role in the pathology of animals and humans

Mikheev¹

2017

Regul. Mech. Biosyst.

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Infectious diseases that are caused by numerous pathogenic microorganisms – bacteria, viruses, protozoa or fungi – can be transmitted from patients or carriers to healthy people or animals. A large group of infectious disease is caused by pathogens of animal infections – zoonoses. The issue of zoonoses is of great significance in human pathology and requires comprehensive study. This is of particular relevance to Ukraine, as the question of prevalence, level within the population and threats to human life and health from zoonoses, though highly important, has remained insufficiently studied. Information about many of these pathogens is absent in the existing scientific literature accessible in Ukraine – both veterinary and medical. This applies, in particular, to a causative agent of viral zoonoses the Borna disease virus or Bornavirus. For this purpose, an analysis of the literature concerning the role of the Bornavirus in the pathology of animals and humans was conducted. It is well known that a large number of pathogens of animal infections (zoonoses), including viral, pose a potential threat to human health. Among these potential threats is the Borna disease virus belonging to the family of Bornaviridae, order Mononegavirales. This order includes representatives of deadly human diseases like rabies (family Rhabdoviridae), Ebola virus (family Filoviridae) and Nipah virus (family Paramyxoviridae). Borna virus disease affects mainly mammals, but can infect birds and even reptiles (Aspid bornavirus). It is established that Bornaviruses have a wide range of natural hosts (horses, sheeps, cats, bats and various birds), including domestic animals, which poses a potential threat to human health. This is evidenced by numerous, although contradictory, research into the role of the Borna disease virus in human pathologies such as schizophrenia, depression, prolonged fatigue syndrome, multiple sclerosis and others. Analysis of the literature clearly shows the important role of the Borna disease virus in a variety of mental and behavioural changes in animals, both wild and domestic. However, the large amount of contradictory data and studies cannot yet provide a clear picture of the role of this virus in human pathology. On the one hand, there are clear data of the presence of RNA of the Bourna disease virus and antibodies to it in patients with psychoneurotic changes. On the other, there is no clear understanding of the infectivity of the virus in humans and its transmission from animals to humans and from person to person. These questions require further research and comprehensive study, particularly on the territory of Ukraine.

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Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population

Cited by 11 publications

References 10 publications

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin

Borna disease virus and its role in the pathology of animals and humans

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