2018
DOI: 10.1016/j.bbrc.2018.01.111
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Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress

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Cited by 47 publications
(28 citation statements)
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References 30 publications
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“…The Consulting the literature showed that the phenolic acid components chlorogenic acid (Xue et al, 2017;Shao, Zhang, Chen, & Sun, 2015) and caffeic acid (Brautigan, Gielata, Heo, Kubicka, & Wilkins, 2018), and the flavonoids scutellarin (Nie et al, 2018;Sun et al, 2018;Tang & Gao, 2019), isoorientin (Huang, Jin et al, 2018;Lin et al, 2016), isovitexin (Lv, 2018), scutellarein (Jiang et al, 2018;Lu, Li, Li, & Asia, 2017;Zheng et al, 2017), luteolin (Niu, Guo, Gan, Bao, & Ren, 2015) and apigenin (Bhattacharya et al, 2018;Masuelli et al, 2017;Cai et al, 2011) had different degrees of inhibition on tumor cells. Among them, caffeic acid, isoorientin, isovitexin, luteolin and apigenin had better antiliver tumor activities.…”
Section: Analysis Of Migration Components In Plasmamentioning
confidence: 99%
“…The Consulting the literature showed that the phenolic acid components chlorogenic acid (Xue et al, 2017;Shao, Zhang, Chen, & Sun, 2015) and caffeic acid (Brautigan, Gielata, Heo, Kubicka, & Wilkins, 2018), and the flavonoids scutellarin (Nie et al, 2018;Sun et al, 2018;Tang & Gao, 2019), isoorientin (Huang, Jin et al, 2018;Lin et al, 2016), isovitexin (Lv, 2018), scutellarein (Jiang et al, 2018;Lu, Li, Li, & Asia, 2017;Zheng et al, 2017), luteolin (Niu, Guo, Gan, Bao, & Ren, 2015) and apigenin (Bhattacharya et al, 2018;Masuelli et al, 2017;Cai et al, 2011) had different degrees of inhibition on tumor cells. Among them, caffeic acid, isoorientin, isovitexin, luteolin and apigenin had better antiliver tumor activities.…”
Section: Analysis Of Migration Components In Plasmamentioning
confidence: 99%
“…The present study examined the mRNA expression levels of XBP-1s, CHOP and caspase-3 by RT-qPCR, which are three key indicators of ERS ( 24 ). Compared with control group mice, the mRNA expression levels of XBP-1s and CHOP were significantly increased in alcohol-induced model mice ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Western blotting was used to analyze GRP78, PERK, p-PERK, eIF-2α, p-eIF-2α, IRE-1α, XBP-1s, CHOP, caspase-3 and cleaved caspase-3 proteins, which are related to ERS in liver tissues of mice ( 24 ). The protein expression levels of p-PERK, p-eIF-2α, XBP-1s, CHOP, caspase-3 and cleaved caspase-3 in the model group were significantly higher compared with the control group, but the expression levels of GRP78, PERK, eIF-2α and IRE-1α did show any significant changes ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Autophagy is best characterized as a survival response, it is a widespread mechanism of a mechanism of programmed cell death, and an important pathway of intracellular component degradation, which is crucial for cell activity and body health. Cells can remove damaged organelles through autophagy to maintain cell homeostasis and provide energy [22]. Most recent studies have reported that autophagy involves many biological events, such as cell proliferation and development, oxidative stress, cell survival, cell senescence, and cell death [49].…”
Section: Discussionmentioning
confidence: 99%