Isovolemic filter-based therapeutic plasma-exchange with fresh frozen plasma is associated with minimal thromboelastometric changes in noncoagulopathic patients

Popescu, Mihai; Marcu, Alexandra; Dinca, Alexandru; Tanase, Andreea; Tomescu, Dana

doi:10.1097/mbc.0000000000000976

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Four studies assessed the effects of TPE on whole blood clotting assays. 13,31,57,58 Three of these studies used albumin as the replacement fluid and one used plasma. Blood samples were collected no more than 30 minutes after the TPE procedure to measure changes in clotting time, clot formation time, and maximum clot firmness.…”

Section: Tpe Effects On Whole Blood Clotting Assaysmentioning

confidence: 99%

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Hemostatic effects of therapeutic plasma exchange: A concise review

Júnior

Hodulik

Barton

et al. 2022

J of Clinical Apheresis

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Therapeutic plasma exchange (TPE) alters the hemostatic balance. Contributing to TPE's hemostatic effects is the mechanical processing of blood in the extracorporeal circuit, circuit anticoagulant, type of replacement fluid, TPE schedule and number of procedures, TPE timing relative to invasive procedures, and removal of nontargeted components such as platelets, coagulation proteins, and cytokines. Although TPE's hemostatic effects are well established, how it impacts the bleeding risk is not clearly understood. In this concise review, we describe the effects of the above TPE‐related factors on hemostatic balance, present data on the effects of TPE on blood hemostasis, including its effects on platelet counts and clotting assays, and review the literature on the impact of TPE‐induced hemostatic changes on TPE‐associated bleeding events. Finally, we discuss risk factors associated with bleeding during TPE and review the literature on TPE‐associated hemostatic effects in the pediatric population.

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Section: Tpe Effects On Whole Blood Clotting Assaysmentioning

confidence: 99%

“…Four studies assessed the effects of TPE on whole blood clotting assays 13,31,57,58 . Three of these studies used albumin as the replacement fluid and one used plasma.…”

Section: Tpe Effects On Clotting Assaysmentioning

confidence: 99%

Hemostatic effects of therapeutic plasma exchange: A concise review

Júnior

Hodulik

Barton

et al. 2022

J of Clinical Apheresis

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A Pilot Study on the Replacement of Fibrinogen with Fibrinogen Concentrates During Therapeutic Plasma Exchange with Mild to Moderate Bleeding Risk—A Comparison with Fresh Frozen Plasma and Albumin Replacement

Zrimsek,

Gubensek,

Marn Pernat

2024

JCM

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Background: Therapeutic plasma exchange (TPE) removes coagulation factors and leads to depletion coagulopathy. The aim of the study was to compare hemostasis between TPE procedures without coagulation factor replacement (electrolyte group), the partial replacement of fibrinogen with fibrinogen concentrates (fibrinogen group) and partial coagulation factors replacement with fresh frozen plasma (partial FFP group). Methods: A total of 73 TPE procedures in patients with fibrinogen levels 1–2 g/L were divided into three study groups depending on clinically estimated bleeding risk. Standard coagulation and ROTEM® tests were performed before and after TPE. Results: Fibrinogen levels before TPE (p = 0.88) and after TPE (p = 0.33) were comparable between the fibrinogen and partial FFP groups. INR and ROTEM® parameters reflected moderately worse hemostasis after TPE with fibrinogen-only replacement compared to partial FFP replacement, which could result in increased bleeding risk. In the electrolyte group, most laboratory tests confirmed the most deranged hemostasis after TPE, as compared to fibrinogen or partial FFP replacement. A mild allergic reaction to FFP infusion was noted during one TPE. No clinically significant bleeding occurred in any of the study groups. Conclusions: Fibrinogen concentrate supplementation and partial FFP replacement can both maintain fibrinogen levels > 1 g/L after TPE, but modest differences in classical coagulation tests and bedside ROTEM® tests favor FFP replacement (NCT03801135).

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Isovolemic filter-based therapeutic plasma-exchange with fresh frozen plasma is associated with minimal thromboelastometric changes in noncoagulopathic patients

Cited by 2 publications

References 25 publications

Hemostatic effects of therapeutic plasma exchange: A concise review

Hemostatic effects of therapeutic plasma exchange: A concise review

A Pilot Study on the Replacement of Fibrinogen with Fibrinogen Concentrates During Therapeutic Plasma Exchange with Mild to Moderate Bleeding Risk—A Comparison with Fresh Frozen Plasma and Albumin Replacement

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