Isoxadifen safening mechanism in sweet corn genotypes with differential response to P450-metabolized herbicides

Paporisch, Amit; Rubin, Baruch

doi:10.1016/j.pestbp.2017.02.002

Cited by 25 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Maize is naturally tolerant to 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicides [86]. A CYP-mediated metabolism of the HPPD inhibitors mesotrione [87] and tembotrione [88] was reported in maize. Several uncharacterized CYP genes have been found to confer resistance to herbicides with different modes of action such as nicosulfuron (ALS inhibitor), mesotrione (HPPD inhibitor), dicamba (synthetic auxin), diflufenzopyr (auxin transport inhibitor), and carfentrazone (protoporphyrinogen oxidase (PPO) inhibitor) in maize [89,90].…”

Section: Herbicide Stressmentioning

confidence: 99%

Role of Cytochrome P450 Enzymes in Plant Stress Response

et al. 2020

View full text Add to dashboard Cite

Cytochrome P450s (CYPs) are the largest enzyme family involved in NADPH- and/or O2-dependent hydroxylation reactions across all the domains of life. In plants and animals, CYPs play a central role in the detoxification of xenobiotics. In addition to this function, CYPs act as versatile catalysts and play a crucial role in the biosynthesis of secondary metabolites, antioxidants, and phytohormones in higher plants. The molecular and biochemical processes catalyzed by CYPs have been well characterized, however, the relationship between the biochemical process catalyzed by CYPs and its effect on several plant functions was not well established. The advent of next-generation sequencing opened new avenues to unravel the involvement of CYPs in several plant functions such as plant stress response. The expression of several CYP genes are regulated in response to environmental stresses, and they also play a prominent role in the crosstalk between abiotic and biotic stress responses. CYPs have an enormous potential to be used as a candidate for engineering crop species resilient to biotic and abiotic stresses. The objective of this review is to summarize the latest research on the role of CYPs in plant stress response.

show abstract

Section: Herbicide Stressmentioning

confidence: 99%

Role of Cytochrome P450 Enzymes in Plant Stress Response

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Safener applied in combination with metolachlor at high rates protected corn from metolachlor injury with no reduction in yield (Viger et al 1991). Protection conferred by safener to a crop has also been suggested to be relevant only under certain environmental conditions that favor reduced enzyme activity or a lower rate of herbicide metabolism in the crop (Paporisch and Rubin 2017). Therefore, the use of a safener is justifiable under conditions in which wheat varieties will suffer from herbicide injury.…”

Section: Fluxofenim Dose-response With Vlcfa-inhibiting Herbicidesmentioning

confidence: 99%

Herbicide safener increases weed-management tools for control of annual grasses in wheat

et al. 2020

View full text Add to dashboard Cite

Annual grass weeds reduce profits of wheat farmers in the Pacific Northwest. The very-long-chain fatty acid elongase (VLCFA)-inhibiting herbicides S-metolachlor and dimethenamid-P could expand options for control of annual grasses, but are not registered in wheat due to crop injury. Our studies evaluated a safener, fluxofenim, applied to wheat seed for protection of nineteen soft white winter wheat varieties from S-metolachlor, dimethenamid-P and pyroxasulfone herbicides, investigated the response of six varieties (UI Sparrow, LWW 15-72223, UI Magic CL+, Brundage 96, UI Castle CL+ and UI Palouse CL+) to incremental doses of fluxofenim, established fluxofenim dose required to optimally protect the varieties from VLCFA-inhibiting herbicides, and assessed the impact of fluxofenim dose on glutathione S-transferase (GST) activity in three wheat varieties (UI Sparrow, Brundage 96 and UI Castle CL+). Fluxofenim increased the biomass of four varieties treated with S-metolachlor or dimethenamid-P herbicides and one variety treated with pyroxasulfone. Three varieties showed tolerance to the herbicides regardless of the fluxofenim treatment. Estimated fluxofenim doses resulting in 10% biomass reduction of wheat ranged from 0.55 g ai kg-1 seed to 1.23 g ai kg-1 seed. Fluxofenim doses resulting in 90% increased biomass to S-metolachlor, dimethenamid-P, and pyroxasulfone ranged from 0.07 to 0.55, 0.09 to 0.73, and 0.30 to 1.03 g ai kg-1 seed, respectively. Fluxofenim at 0.36 g ai kg-1 seed increased GST activity in UI Castle CL+, UI Sparrow and Brundage 96 by 58%, 30% and 38%, respectively. These results suggest that fluxofenim would not damage wheat seedlings up to 3x the rate labeled for sorghum, and fluxofenim protects soft white winter wheat varieties from S-metolachlor, dimethenamid-P or pyroxasulfone injury at the herbicide rates evaluated.

show abstract

“…Safener pathways of induction are not well understood, but studies suggest that they are related to cytP450, GST, glycosyltransferase (GT) and ABC transporter enzymes. 22,[42][43][44] The safener isoxadifen-ethyl allows the selective use of fenoxaprop-p-ethyl in rice. 15,45 The effect of this safener occurs for multiple crops for multiple herbicide modes of action, such as rice to fenoxapropp-ethyl, 45 corn to foramsulfuron 46 and tembotrione.…”

Section: Discussionmentioning

confidence: 99%

The safener isoxadifen‐ethyl confers fenoxaprop‐p‐ethyl resistance on a biotype of Echinochloa crus‐galli

Cutti

Rigon

Girelli

et al. 2022

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND: Some herbicides are commercially formulated with safeners to increase crop selectivity. Fenoxaprop-p-ethyl is formulated with the safener isoxadifen-ethyl for Echinochloa crus-galli control in rice. Safeners act on crops by increasing herbicide metabolism, but this effect may also occur in weeds. The objective of this study was to investigate the effect of the safener isoxadifen-ethyl on the resistance to fenoxaprop-p-ethyl in a biotype of E. crus-galli.RESULTS: A screening of 52 biotypes identified lack of control in the biotype SANTPAT-R treated with the recommended dose of 69 g ha −1 of the commercial formulation of fenoxaprop-p-ethyl with the safener isoxadifen-ethyl. While this biotype survived doses greater than 2208 g ha −1 of the formulation fenoxaprop-p-ethyl + isoxadifen-ethyl, it was killed with 69 g ha −1 of fenoxaprop-p-ethyl without the safener. A glutathione-s-transferase (GST) enzymes inhibitor reduced the resistance factor in two dose-response curves. A minor effect of a CytP450 inhibitor was observed. The previous spraying of the safener isoxadifen-ethyl followed by fenoxaprop-p-ethyl induced survival in the resistant but not in the susceptible biotype. The GST1 and GSTF1 genes were up-regulated in the resistant biotype. ACCase gene mutations were not found, and no cross-resistance to other ACCase inhibitors was identified.CONCLUSION: The safener isoxadifen-ethyl present in the commercial herbicide formulation of fenoxaprop-p-ethyl is associated with resistance in the E. crus-galli SANTPAT-R biotype. This resistance is related with herbicide metabolization mediated by GST pathways. This is the first field-selected weed biotype with herbicide resistance due to safener presence in the sprayed formulation.

show abstract

Isoxadifen safening mechanism in sweet corn genotypes with differential response to P450-metabolized herbicides

Cited by 25 publications

References 21 publications

Role of Cytochrome P450 Enzymes in Plant Stress Response

Role of Cytochrome P450 Enzymes in Plant Stress Response

Herbicide safener increases weed-management tools for control of annual grasses in wheat

The safener isoxadifen‐ethyl confers fenoxaprop‐p‐ethyl resistance on a biotype of Echinochloa crus‐galli

Contact Info

Product

Resources

About