Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity

Harada, Shoji; Agarwal, D. P.; Goedde, H. W.

doi:10.1007/978-1-4757-1419-7_4

Cited by 66 publications

(80 citation statements)

References 11 publications

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“…The previously reported [4] genetic polymorphism of ALDH2 in Oriental populations was confirmed and probable genetic variants of ALDH3, resembling those described by Teng [9] were identified in the European population. No variations of the ALDHI and ALDH4 isozymes were encountered.…”

Section: Discussionsupporting

confidence: 80%

“…This variant which was found to occur with a frequency of 54%, is presumably identical to that previously reported in Oriental populations [4] and recently characterised by immunological analysis [10]. No variants of this type were identified on electrophoretic screening of liver specimens (n=>200) from N. Europeans and indeed the ALDH1 and ALDH4 isozymes were found to be invariant.…”

Section: Genetic" Variationsupporting

confidence: 84%

“…Genetically determined deficiency of ALDH has been identified in Oriental populations and associated with a marked alcohol-induced flush response in individuals homozygous for the defect [4]. This deficiency is confined exclusively to the ALDH2 components and thus it seems likely that different groups of ALDH isozymes are determined by independent structural genes.…”

Section: Hopkinson D a I Santisteban S Povey And M Smith Biomentioning

confidence: 99%

See 2 more Smart Citations

Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH)

Hopkinson

Santistéban

Povey

et al. 1985

Alcohol

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Section: Discussionsupporting

confidence: 80%

Section: Genetic" Variationsupporting

confidence: 84%

Section: Hopkinson D a I Santisteban S Povey And M Smith Biomentioning

confidence: 99%

See 1 more Smart Citation

Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH)

Hopkinson

Santistéban

Povey

et al. 1985

Alcohol

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“…The frequencies of poor metabolizers within each ethnic group are given in (Teng et al, 1979;Harada et al, 1980) but are much more rare among Caucasians (Harada et al, 1978). The frequency of slow acetylators of isoniazid differs slightly between Japanese and Chinese, 10-15% and 22%, respectively, yet both of these frequencies contrast markedly with that among Caucasians, 60% (Ellard, 1976).…”

Section: Methodsmentioning

confidence: 99%

Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.

Jurima¹,

Inaba²,

Kadar³

et al. 1985

Brit J Clinical Pharma

106

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The genetically controlled mephenytoin p(4′)‐hydroxylation capacity was determined in 118 Caucasians and 70 Orientals. After an oral dose of 50 or 100 mg of racemic mephenytoin, the amount of p(4′)‐ hydroxymephenytoin in 24 h urine was measured by gas chromatography. Bimodal distribution was found with 9/70 (13%) Orientals and 5/118 (4%) Caucasians demonstrating deficient p(4′)‐hydroxylation. The statistically significant difference between Orientals and Caucasians (P less than 0.05) was accounted for by the high incidence of poor metabolizers among the Japanese subjects, 7/31 (23%). The frequency among Chinese subjects, 2/39 (5%), was similar to the frequency among Caucasians.

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“…It should be able to clarify specific brain functions under various environmental and lifestyle factors including the effects of alcohol. Recently, several studies examined how different genetic propensities to produce aldehyde dehydrogenase (ALDH2) modulate the acute effects of alcohol intake (7)(8)(9). ALDH2 genotypes showed different effects of alcohol intake on EEG response, event-related potential (ERP) response, pulse rate, and facial flushing (10-13).…”

Section: Introductionmentioning

confidence: 99%

Application of specific brain function evaluation by optical topography

Obata

Morimoto

Takeshita

et al. 2003

Environ Health Prev Med

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Objectives: To use the evaluation of a specific brain function obtained by optical topography. This system uses a non invasive method to measure brain function, unlike other major systems.Methods: Twelve optical fibers were attached to the subject's head. Hemodynamic changes in the motor cortex were measured during finger tapping before and after alcohol intake for each ALDH2 genotype.Results: Different hemodynamic changes in the motor cortex were observed among the ALDH2 genotypes.Conclusions: Optical topography is a useful tool for evaluating specific brain functions. Further research is needed on the relations between various environmental factors and brain functions by optical topography.

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Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity

Cited by 66 publications

References 11 publications

Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH)

Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH)

Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.

Application of specific brain function evaluation by optical topography

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