In this paper, we introduce the notion of relative K-equi-stability (RKES) to characterize the uniformly continuous dependence of (weak) solutions on external disturbances for nonlinear parabolic PDE systems. Based on the RKES, we prove the input-to-state stability (ISS) in the spatial sup-norm for a class of nonlinear parabolic PDEs with either Dirichlet or Robin boundary disturbances. An example concerned with a super-linear parabolic PDE with Robin boundary condition is provided to illustrate the obtained ISS results. Besides, as an application of the notion of RKES, we conduct stability analysis for a class of parabolic PDEs in cascade coupled over the domain or on the boundary of the domain, in the spatial and time sup-norm, and in the spatial sup-norm, respectively. The technique of De Giorgi iteration is extensively used in the proof of the results presented in this paper.