ISSLS Prize Winner

Brown, Stephen H.M.; Gregory, Diane E.; Carr, J. Austin; Ward, Samuel R.; Masuda, Koichi; Lieber, Richard L.

doi:10.1097/brs.0b013e318212b44b

Cited by 60 publications

(29 citation statements)

References 25 publications

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“…Human muscle fibers demonstrate different passive mechanical properties compared to bundles, which contain a connective tissue matrix layer (i.e., perimysium) that individual fibers do not (Fridén and Lieber, 2003;Lieber et al, 2003;Ward et al, 2009). Differences between fibers and bundles manifest themselves functionally as well in mouse Lieber, 2011, 2018), rat (Brown et al, 2011a), and rabbit (Brown et al, 2011b) skeletal muscle: bundles exhibit a larger stress at a given strain that is non-linear, whereas individual fibers often demonstrate a highly linear response (Figure 2). In our sample, linear fits to fiber stressstrain data explained over 90% of the experimental variability.…”

Section: Discussionmentioning

confidence: 99%

Non-linear Scaling of Passive Mechanical Properties in Fibers, Bundles, Fascicles and Whole Rabbit Muscles

et al. 2020

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Defining variations in skeletal muscle passive mechanical properties at different size scales ranging from single muscle fibers to whole muscles is required in order to understand passive muscle function. It is also of interest from a muscle structural pointof-view to identify the source(s) of passive tension that function at each scale. Thus, we measured passive mechanical properties of single fibers, fiber bundles, fascicles, and whole muscles in three architecturally diverse muscles from New Zealand White rabbits (n = 6) subjected to linear deformation. Passive modulus was quantified at sarcomere lengths across the muscle's anatomical range. Titin molecular mass and collagen content were also quantified at each size scale, and whole muscle architectural properties were measured. Passive modulus increased non-linearly from fiber to whole muscle for all three muscles emphasizing extracellular sources of passive tension (p < 0.001), and was different among muscles (p < 0.001), with significant muscle by size-scale interaction, indicating quantitatively different scaling for each muscle (p < 0.001). These findings provide insight into the structural basis of passive tension and suggest that the extracellular matrix (ECM) is the dominant contributor to whole muscle and fascicle passive tension. They also demonstrate that caution should be used when inferring whole muscle properties from reduced muscle size preparations such as muscle biopsies.

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Section: Discussionmentioning

confidence: 99%

Non-linear Scaling of Passive Mechanical Properties in Fibers, Bundles, Fascicles and Whole Rabbit Muscles

et al. 2020

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“…During IVD degeneration the multifidus muscle is constantly remodeling [8,7,9,14] and if elements of this remodeling begin before the macrophage transition this could provide a candidate mechanism to underpin this process. One possibility is the muscle fiber type transformation from slow (oxidative) to fast (glycolytic) that is significant by six months after IVD lesion [8,7], with a non-significant tendency at three months (19.8% lower slow fibers proportion than controls) [8,14]. Altered skeletal muscle microenvironment secondary to slow muscle fiber loss could affect the macrophage population and hyperalgesia [23,33,34].…”

Section: M1 Macrophages and Multifidus Structural Remodelingmentioning

confidence: 99%

“…Acutely after IVD injury the deep back muscle, multifidus, undergoes rapid atrophy with neural inhibition [12,13]. In the subacute/early chronic period muscle fibrosis, fatty infiltration and transformation of muscle fibers from slow-tofast develops [8,7,14,9]. This progresses to muscle tissue atrophy with chronic degeneration [15].…”

Section: Introductionmentioning

confidence: 99%

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

et al. 2018

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“…Experimentally induced intervertebral disc degeneration in the cat induces pathophysiologic changes to the MF 62. In a rabbit model, the MF becomes stiffer, both in individual fibers and in fiber bundles, in response to experimentally induced intervertebral disc degeneration, and a stiffer muscle can alter the biomechanical properties of the spine stabilizing system 62.…”

Section: Introductionmentioning

confidence: 99%

Muscle Control and Non-specific Chronic Low Back Pain

Russo¹,

Deckers

Eldabe

et al. 2018

Neuromodulation: Technology at the Neural Interface

144

129

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ObjectivesChronic low back pain (CLBP) is the most prevalent of the painful musculoskeletal conditions. CLBP is a heterogeneous condition with many causes and diagnoses, but there are few established therapies with strong evidence of effectiveness (or cost effectiveness). CLBP for which it is not possible to identify any specific cause is often referred to as non‐specific chronic LBP (NSCLBP). One type of NSCLBP is continuing and recurrent primarily nociceptive CLBP due to vertebral joint overload subsequent to functional instability of the lumbar spine. This condition may occur due to disruption of the motor control system to the key stabilizing muscles in the lumbar spine, particularly the lumbar multifidus muscle (MF).MethodsThis review presents the evidence for MF involvement in CLBP, mechanisms of action of disruption of control of the MF, and options for restoring control of the MF as a treatment for NSCLBP.ResultsImaging assessment of motor control dysfunction of the MF in individual patients is fraught with difficulty. MRI or ultrasound imaging techniques, while reliable, have limited diagnostic or predictive utility. For some patients, restoration of motor control to the MF with specific exercises can be effective, but population results are not persuasive since most patients are unable to voluntarily contract the MF and may be inhibited from doing so due to arthrogenic muscle inhibition.ConclusionsTargeting MF control with restorative neurostimulation promises a new treatment option.

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ISSLS Prize Winner

Cited by 60 publications

References 25 publications

Non-linear Scaling of Passive Mechanical Properties in Fibers, Bundles, Fascicles and Whole Rabbit Muscles

Non-linear Scaling of Passive Mechanical Properties in Fibers, Bundles, Fascicles and Whole Rabbit Muscles

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

Muscle Control and Non-specific Chronic Low Back Pain

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