The ubiquity of social and online media networks, the credulousness of online communities, coupled with limited accountability pose a risk of mis-, dis-, mal-, information (mis-dis-mal-information)—the intentional or unintentional spread of false, misleading and right information related to agri-food topics. However, agri-food mis-dis-malinformation in social media and online digital agricultural communities of practice (CoPs) remains underexplored. There is also a limited theoretical and conceptual foundation for understanding mis-dis-malinformation topics in the agri-food sectors. The study aims to review mis-dis-malinformation literature and offer a framework to help understand agri-food mis-dis-malinformation in social media and online CoPs. This paper performs a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The review shows that many disciplines, particularly communication, social media studies, computer science, health studies, political science and journalism, are increasingly engaging with mis-dis-malinformation research. This systematic research generates a framework based on six thematic categories for holistically understanding and assessing agri-food mis-dis-malinformation in social and online media communities. The framework includes mis-dis-malinformation characterization, source identification, diffusion mechanisms, stakeholder impacts, detection tactics, and mis-dis-malinformation curtailment and countermeasures. The paper contributes to advancing the emerging literature on ‘controversial topics’, ‘misinformation’, and ‘information integrity’ of the virtual agri-food advisory services. This is the first attempt to systematically analyze and incorporate experience from diverse fields of mis-dis-malinformation research that will inform future scholarly works in facilitating conversations and advisory efforts in the agri-food sector.