Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor

Monnard, Cathríona R.; Fares, Elie-Jacques; Calonne, Julie; Miles-Chan, Jennifer L.; Montani, Jean‐Pierre; Durrer, Dominique; Schütz, Y.; Dulloo, Abdul G.

doi:10.3389/fendo.2017.00130

Cited by 30 publications

(43 citation statements)

References 32 publications

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“…Our results at baseline suggest indeed that CT individuals have a slightly higher Tc. However, a recent study pointed out the difficulty of reliably measuring Tc in individuals (37). For the moment, we cannot firmly conclude whether CT people have undergone any metabolic adaptation or have different Tc, and more in-depth analysis of energy homeostasis could be valuable.…”

Section: Discussionmentioning

confidence: 99%

Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue

Ling

Carayol

Galusca

et al. 2019

The American Journal of Clinical Nutrition

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Background Constitutional thinness (CT) is a state of low but stable body weight (BMI ≤18 kg/m2). CT subjects have normal-range hormonal profiles and food intake but exhibit resistance to weight gain despite living in the modern world's obesogenic environment. Objective The goal of this study is to identify molecular mechanisms underlying this protective phenotype against weight gain. Methods We conducted a clinical overfeeding study on 30 CT subjects and 30 controls (BMI 20–25 kg/m2) matched for age and sex. We performed clinical and integrative molecular and transcriptomic analyses on white adipose and muscle tissues. Results Our results demonstrate that adipocytes were markedly smaller in CT individuals (mean ± SEM: 2174 ± 142 μm 2) compared with controls (3586 ± 216 μm2) (P < 0.01). The mitochondrial respiratory capacity was higher in CT adipose tissue, particularly at the level of complex II of the electron transport chain (2.2-fold increase; P < 0.01). This higher activity was paralleled by an increase in mitochondrial number (CT compared with control: 784 ± 27 compared with 675 ± 30 mitochondrial DNA molecules per cell; P < 0.05). No evidence for uncoupled respiration or “browning” of the white adipose tissue was found. In accordance with the mitochondrial differences, CT subjects had a distinct adipose transcriptomic profile [62 differentially expressed genes (false discovery rate of 0.1 and log fold change >0.75)], with many differentially expressed genes associating with positive metabolic outcomes. Pathway analyses revealed an increase in fatty acid oxidation ( P = 3 × 10−04) but also triglyceride biosynthesis (P = 3.6 × 10−04). No differential response to the overfeeding was observed in the 2 groups. Conclusions The distinct molecular signature of the adipose tissue in CT individuals suggests the presence of augm ented futile lipid cycling, rather than mitochondrial uncoupling, as a way to increase energy expenditure in CT individuals. We propose that increased mitochondrial function in adipose tissue is an important mediator in sustaining the low body weight in CT individuals. This knowledge could ultimately allow more targeted approaches for weight management treatment strategies. This trial was registered at clinicaltrials.gov as NCT02004821.

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Section: Discussionmentioning

confidence: 99%

Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue

Ling

Carayol

Galusca

et al. 2019

The American Journal of Clinical Nutrition

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“…If the system is performing normally, the data and wellness points are forwarded each 30 min if changes have been registered in HR, HRV, temperature, oxygen saturation or sweat parameters. This time interval has been selected after performing some previous measures and consulting documentation on the variation of the parameters considered on this paper such as [ 41 , 42 ]. The accelerometer and pressure sensors may vary more frequently, whereas body temperature and oxygen saturation are parameters that remain constant for larger periods of time.…”

Section: Methodsmentioning

confidence: 99%

Physical Wellbeing Monitoring Employing Non-Invasive Low-Cost and Low-Energy Sensor Socks

García

Parra

Jiménez

et al. 2018

Sensors

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Determining and improving the wellbeing of people is one of the priorities of the OECD countries. Nowadays many sensors allow monitoring different parameters in regard to the wellbeing of people. These sensors can be deployed in smartphones, clothes or accessories like watches. Many studies have been performed on wearable devices that monitor certain aspects of the health of people, especially for specific diseases. In this paper, we propose a non-invasive low-cost and low-energy physical wellbeing monitoring system that provides a wellness score based on the obtained data. We present the architecture of the system and the disposition of the sensors on the sock. The algorithm of the system is presented as well. The wellness threshold evaluation module allows determining if the monitored parameter is within healthy ranges. The message forwarding module allows decreasing the energy consumption of the system by detecting the presence of alerts or changes in the data. Finally, a simulation was performed in order to determine the energy consumption of the system. Results show that our algorithm allows saving 44.9% of the initial energy in 10,000 min for healthy people.

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“…Axillary and wrist skin surface temperature records were shown to be largely contaminated by changes in environmental temperature [ 36 - 39 ]. The recent availability of an oral temperature pill has enabled the continuous recording of internal body temperature, yet only for durations that match the gastro-intestinal transit time, ie, ~24-48 hours [ 40 , 41 ]. Previous work by others highlighted the reduced influence of environmental temperature changes on skin surface temperature measurements taken at the upper-anterior chest wall [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study

Komarzynski¹,

Huang²,

Innominato³

et al. 2018

J Med Internet Res

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BackgroundExperimental and epidemiologic studies have shown that circadian clocks’ disruption can play an important role in the development of cancer and metabolic diseases. The cellular clocks outside the brain are effectively coordinated by the body temperature rhythm. We hypothesized that concurrent measurements of body temperature and rest-activity rhythms would assess circadian clocks coordination in individual patients, thus enabling the integration of biological rhythms into precision medicine.ObjectiveThe objective was to evaluate the circadian clocks’ coordination in healthy subjects and patients through simultaneous measurements of rest-activity and body temperature rhythms.MethodsNoninvasive real-time measurements of rest-activity and chest temperature rhythms were recorded during the subject’s daily life, using a dedicated new mobile electronic health platform (PiCADo). It involved a chest sensor that jointly measured accelerations, 3D orientation, and skin surface temperature every 1-5 min and relayed them out to a mobile gateway via Bluetooth Low Energy. The gateway tele-transmitted all stored data to a server via General Packet Radio Service every 24 hours. The technical capabilities of PiCADo were validated in 55 healthy subjects and 12 cancer patients, whose rhythms were e-monitored during their daily routine for 3-30 days. Spectral analyses enabled to compute rhythm parameters values, with their 90% confidence limits, and their dynamics in each subject.ResultsAll the individuals displayed a dominant circadian rhythm in activity with maxima occurring from 12:09 to 20:25. This was not the case for the dominant temperature period, which clustered around 24 hours for 51 out of 67 subjects (76%), and around 12 hours for 13 others (19%). Statistically significant sex- and age-related differences in circadian coordination were identified in the noncancerous subjects, based upon the range of variations in temperature rhythm amplitudes, maxima (acrophases), and phase relations with rest-activity. The circadian acrophase of chest temperature was located at night for the majority of people, but it occurred at daytime for 26% (14/55) of the noncancerous people and 33% (4/12) of the cancer patients, thus supporting important intersubject differences in circadian coordination. Sex, age, and cancer significantly impacted the circadian coordination of both rhythms, based on their phase relationships.ConclusionsComplementing rest-activity with chest temperature circadian e-monitoring revealed striking intersubject differences regarding human circadian clocks’ coordination and timing during daily routine. To further delineate the clinical importance of such finding, the PiCADo platform is currently applied for both the assessment of health effects resulting from atypical work schedules and the identification of the key determinants of circadian disruption in cancer patients.

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Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor

Cited by 30 publications

References 32 publications

Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue

Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue

Physical Wellbeing Monitoring Employing Non-Invasive Low-Cost and Low-Energy Sensor Socks

Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study

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