1999
DOI: 10.1177/090591999900900302
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Issues in Cyclosporine Drug Substitution: Implications for Patient Management

Abstract: Substantial improvements in short-term and long-term outcomes for kidney transplant recipients have resulted from better use of existing immunosuppressive agents and newer treatment options. Calcineurin inhibitors (eg, cyclosporine and tacrolimus) remain the foundation of immunosuppressive therapy. These agents are considered critical-dose drugs because of their narrow therapeutic range, variable pharmacokinetics, formulation-dependent bioavailability, and negative clinical consequences of underdosing or overd… Show more

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“…Both target calcineurin (CN), which is an integral enzyme involved in the activation of T cells. Although very effective in inhibiting the rejection response, the use of both agents is associated with significant side effects, including nephrotoxicity, hypertension, hyperlipidemia, and neurotoxicity (3)(4)(5). It is believed that these toxic side effects are, in part, a direct result of CN inhibition in nonlymphoid tissues (6 -8).…”
mentioning
confidence: 97%
“…Both target calcineurin (CN), which is an integral enzyme involved in the activation of T cells. Although very effective in inhibiting the rejection response, the use of both agents is associated with significant side effects, including nephrotoxicity, hypertension, hyperlipidemia, and neurotoxicity (3)(4)(5). It is believed that these toxic side effects are, in part, a direct result of CN inhibition in nonlymphoid tissues (6 -8).…”
mentioning
confidence: 97%