This study develops an integrated methodology to evaluate and prioritize suitable sites for many human activities associated with sustainable marine development, such as wind farms, fish farms, and marine nature reserves. The methodological framework includes identifying proposed locations for ship trajectory, laying oil pipelines, oil platforms, and all those affecting these locations, including river plumes and sub-marine springs, using geographic information systems (GIS), remote sensing, and multi-natural-criteria methods. Therefore, maps were produced and then re-classified into three categories: low, moderate, and extreme ability training. The results provide a decision-making process regarding offshore wind farming, fish farming, and the establishment of marine reserves. The outputs of this work contribute to ensuring the sustainable spatial development of the marine ecosystem through renewable energy resources and nutrition solutions.