The study was conducted to assess the safety and security measures at Buabeng-Fiema Monkey Sanctuary in Ghana. The study used a case study design. Interviews and observation were used to gather data from 10 management staff. The study revealed that safety signs, a first aid box, a fire extinguisher, washrooms, dustbins, tour guides, security personnel, visitors seating and an emergency unit were available at the site. However, CCTV cameras, metal detectors and ambulances were not available. The study further established that safety and security measures at the site were generally inadequate; management did not consider the site to be under any threat since the monkeys had never caused any severe harm or injury to tourists, which would call for stringent security measures. The study recommends that tourism stakeholders should endevour to provide CCTV cameras, metal detectors and ambulances to deal with any incidents that may arise at the destination.