Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests

Пташинский, Р. И.; Frigo, N V; Жукова, О. В.; Ptashinskiy, R. I.; Negasheva, E.S.

doi:10.17116/klinderma201615160-68

Klin. dermatol. venerol.

2016

DOI: 10.17116/klinderma201615160-68

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Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests

Р. И. Пташинский¹,

N V Frigo²,

О. В. Жукова³

et al.

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Cited by 3 publications

References 27 publications

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The problem of interdisciplinary interaction in valuation of syphilis screening results

Хамаганова¹,

Malyarenko²,

Маляренко³

et al. 2016

Klin. dermatol. venerol.

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1 ГБоУ вПо «Российский национальный исследовательский медицинский университет им. н.И. Пирогова», Москва, Россия, 117997; 2 ГБУз «Московский научно-практический центр дерматовенерологии и косметологии» Департамента здравоохранения Москвы, Москва, Россия, 119071 в конце ХХ века был отмечен значительный рост заболеваемости сифилисом в разных странах европы, США, Австралии. в России за время эпидемии в период 1990-2000 гг. переболели сифилисом более 2,5 млн человек. в настоящее время в структуре заболеваемости сифилисом сохраняется рост скрытых и поздних форм на фоне снижения показателя общей заболеваемости. особое значение имеют ошибки в диагностике сифилитической инфекции. в статье приведены два клинических наблюдения сифилиса скрытого неуточненного как раннего или позднего у женщин, обращавшихся к акушерам-гинекологам в связи с бесплодием. в представленных случаях врачи руководствовались отрицательными результатами нетрепонемных тестов (например, реакции микропреципитации), игнорируя положительные результаты трепонемных тестов (реакции пассивной гемагглютинации), что привело к задержке в установлении диагноза сифилиса.

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The problem of interdisciplinary interaction in valuation of syphilis screening results

Хамаганова¹,

Malyarenko²,

Маляренко³

et al. 2016

Klin. dermatol. venerol.

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Early congenital syphilis: solved and unresolved problems of diagnosis

Matyskina

Taranushenko

2019

Ross. vestn. perinatol. pediatr.

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Objective. To analyze the results of clinical and laboratory studies of children born to women with syphilitic infection, and select the most clinically significant criteria to optimize the diagnosis of early congenital syphilis. Methods. A comprehensive clinical and laboratory examination of 547 newborns born to women with a syphilitic infection. Results. The diagnostic sensitivity of the enzyme immunoassay with the determination of specific IgM was 86.6%, the polymerase chain reaction with the detection of Treponema pallidum DNA was 91.6%. Conclusion. The examination of newborns from mothers with a syphilitic infection can be optimized by reducing the number of laboratory techniques (microprecipitation reaction and passive haemagglutination reaction), subject to the mandatory determination of specific IgM and IgG in the first day of life, followed by further confirmation of diagnostics (IgG titer dynamics and the determination of the presence of T. pallidum DNA, as well as instrumental methods of research).

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Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens

Shpilevaya

Валентиновна²,

Katunin

et al. 2021

Vestnik dermatologii i venerologii

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The aim - to find the optimal attributing rules to distinguish groups of latent stages of syphilis and false positive serological tests of using multivariate discriminant analysis Material and methods. The objects of the study were serum samples from patients with late latent (N=34) syphilis and false positive serological tests (N=31). The samples were studied to determine IgG and IgM levels using indirect immunofluorescent reaction with immunochip containing recombinant antigens T. pallidum Results The mathematical model allows to differentiate with a high degree of confidence patients with late latent syphilis and with false-positive serological reactions to syphilis. Conclusions. . Multivariate discriminant analysis makes possible to create reliable mathematical models to classify patients with late latent syphilis and with false-positive serological reactions to syphilis.

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Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests

Cited by 3 publications

References 27 publications

The problem of interdisciplinary interaction in valuation of syphilis screening results

The problem of interdisciplinary interaction in valuation of syphilis screening results

Early congenital syphilis: solved and unresolved problems of diagnosis

Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens

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