Cyber criminals continue targeting organizations' accounting information mostly because of its sensitivity and high value. This leads to devastating losses that impact the confidentiality, integrity, and availability of such information. General Information Technology Controls related to computer operations or GITC-CO are critical in ensuring the security, integrity, completeness, and reliability of accounting information. Per the literature reviewed, traditional methodologies do not necessarily promote an effective assessment of these types of controls in organizations, preventing the implementation of required controls and/or the exclusion of unnecessary controls. The aim of this research is to develop an assessment methodology, based on Grey Systems Theory, that will adequately address weaknesses identified in traditional assessment methodologies, resulting in a more accurate selection of controls. Through a case evaluation, the approach proved successful in providing a more precise and complete evaluation of GITC-CO in organizations.