It Is High Time That We Define Axial Psoriatic Arthritis

Chandran, Vinod

doi:10.3899/jrheum.200103

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Spondyloarthritis (SpA) encompasses a group of overlapping disorders, namely ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, undifferentiated SpA and non-radiographic axial SpA 1. Psoriatic arthritis (PsA) is a chronic, inflammatory musculoskeletal disease2–4 that affects up to 30% of patients with psoriasis5 6 and typically manifests as peripheral arthritis, enthesitis, dactylitis and skin and nail changes 7 8. Between 20% and 75% of patients with PsA have axial involvement (axPsA) and present with additional symptoms, such as back pain that might have inflammatory characteristics including morning stiffness 3 9…”

Section: Introductionmentioning

confidence: 99%

“…Back pain in patients with axPsA is caused by inflammation in sacroiliac joints and/or spine that over time might result into development of structural damage including radiographic sacroiliitis, syndesmophytes and ankylosis. AxPsA is associated with more severe disease and patients with axial involvement often experience worse pain, significantly impaired physical function and overall activity and reduced quality of life compared with patients without axial involvement 8 9…”

Section: Introductionmentioning

confidence: 99%

“…AxPsA is associated with more severe disease and patients with axial involvement often experience worse pain, significantly impaired physical function and overall activity and reduced quality of life compared with patients without axial involvement. 8 9 …”

Section: Introductionmentioning

confidence: 99%

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Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study

Proft

Lüders

Hunter

et al. 2022

Annals of the Rheumatic Diseases

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ObjectivesTo evaluate a dermatologist-centred screening tool followed by a structured rheumatological examination including MRI of sacroiliac joints and spine for the recognition of psoriatic arthritis with axial involvement (axPsA).MethodsThis was a prospective multicentre study. Adult patients with a confirmed diagnosis of psoriasis who had chronic back pain (≥3 months), onset <45 years and had not been treated with any biologic or targeted synthetic disease-modifying antirheumatic drug in the 12 weeks before screening were referred to a specialised rheumatology clinic. A rheumatological investigation including clinical, laboratory and genetic assessments as well as imaging with conventional radiography and MRI of sacroiliac joints and spine was performed. The primary outcome of the study was the proportion of patients diagnosed with axPsA among all referred patients with PsO.ResultsRheumatologists examined 100 patients of those who qualified for referral. 14 patients (including 3 with both axial and peripheral involvement) were diagnosed with axPsA and 5 were diagnosed with peripheral PsA solely. All patients diagnosed with axPsA had active inflammatory and/or structural (post)inflammatory changes in the sacroiliac joints and/or spine on imaging. In five patients, MRI changes indicative of axial involvement were found only in the spine. All but one patient with PsA (13/14 with axPsA and 5/5 with pPsA) fulfilled the Classification Criteria for Psoriatic Arthritis criteria for PsA. The Assessment of SpondyloArthritis International Society criteria for axSpA were fulfilled in 9 (64.3%) patients diagnosed with axPsA.ConclusionsApplying a dermatologist-centred screening tool may be useful for the early detection of axPsA in at-risk patients with psoriasis .

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study

Proft

Lüders

Hunter

et al. 2022

Annals of the Rheumatic Diseases

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Axial involvement in psoriatic arthritis: An update for rheumatologists

Poddubnyy

Jadon

Bosch

et al. 2021

Seminars in Arthritis and Rheumatism

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Axial Involvement in Psoriatic Arthritis: Effect on Peripheral Arthritis and Differential Features With Axial Spondyloarthritis in South America

2021

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Reported data of axial involvement in psoriatic arthritis (PsA) are variable (25–70%). This variability is mainly linked to different ways of defining this feature. Gladman1 established that the prevalence of axial involvement in PsA was close to 50% and that it is associated with HLA-B27. Likewise, psoriasis (PsO) spondylitis, unlike ankylosing spondylitis (AS), is characterized by not having a greater preponderance of the male sex, greater skin involvement, and a less severe course.2

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It Is High Time That We Define Axial Psoriatic Arthritis

Abstract: has received research grants from AbbVie and Celgene. His spouse is an employee of Eli Lilly.

Cited by 4 publications

References 17 publications

Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study

Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study

Axial involvement in psoriatic arthritis: An update for rheumatologists

Axial Involvement in Psoriatic Arthritis: Effect on Peripheral Arthritis and Differential Features With Axial Spondyloarthritis in South America

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