It's all about sex: gender, lung development and lung disease

Carey, Michelle A.; Card, Jeffrey W.; Voltz, James W.; Arbes, Samuel J.; Germolec, Dori R.; Korach, Kenneth S.; Zeldin, Darryl C.

doi:10.1016/j.tem.2007.08.003

Cited by 352 publications

(318 citation statements)

References 69 publications

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“…Sex also affects airway inflammation and the prevalence and severity of many major lung diseases, including pulmonary fibrosis, asthma, and lung cancer. Data from both human and animal studies indicate that sex hormones might contribute to disease pathogenesis or serve as protective factors, depending on the disease involved [21]. Traditionally, COPD has been regarded a male-specific disease owing to the difference in the prevalence of smokers between the sexes [22].…”

Section: Discussionmentioning

confidence: 99%

Do Birth Season and Sex Affect Adult Lung Function as Early Life Factors?

Kim¹,

Park²

2017

Health

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Objectives: Although lung function decline is a normal ageing process, it can be potentiated by risk factors. However, the potential impact of early life factors on lung function decline has been scarcely studied. The aim of this study was to investigate the potential correlation between birth season and adult lung function. Methods: We enrolled 1008 South Korean patients (530 men and 478 women; age range, 40 -80 years) who were hospitalized for urological surgery, irrespective of respiratory disease. All patients underwent the pulmonary function test before any surgery or procedure. Based on their birth season, the patients were divided into two groups (spring, summer, and fall vs. winter). Results: Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1 % predicted of men born in winter were lower than those of men born in other seasons. Univariate and multivariate analyses using linear regression models also showed that birth season was a significant predictive factor for FVC, FEV1, and FEV1 % predicted in men. However, birth season was not correlated with lung function in women. Among male ever-smokers, FEV1 and FEV1 % predicted were lower for men born in winter than for those born in other seasons. Conclusions: Unlike women, men born in winter had lower lung function than did men born in other seasons. These results suggest that birth season might be an early life factor that predicts airway function. Furthermore, birth season has different effects on adult lung function depending on the patient's sex.

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Section: Discussionmentioning

confidence: 99%

Do Birth Season and Sex Affect Adult Lung Function as Early Life Factors?

Kim¹,

Park²

2017

Health

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“…O predomínio de sintomas de asma e rinite no sexo feminino na adolescência tem sido relatado por outros autores 22,23,24 . Vários fatores já foram descritos para explicar esses achados, dentre eles, o menor calibre das vias aéreas, fatores hormonais e maior exposição a alérgenos específicos do gênero 24,25,26,27 . No presente estudo, observou-se também que as adolescentes tiveram significativamente maior risco de apresentar a comorbidade asma-rinite e asma-rinoconjuntivite, corroborando com o achado de uma taxa significativamente maior de tosse seca noturna no gênero feminino.…”

Section: Discussionunclassified

Prevalência e associação de asma e rinite em adolescentes de 13 e 14 anos de Fortaleza, Ceará, Brasil

2011

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This study aimed to measure the prevalence rates for asthma and rhinitis and the association between the two conditions. This was a cross-sectional study of 3,015 adolescents (13-14 (p = 0.037 and p = 0.004, respectively). The study can help call health professionals' attention to the importance of an integrated approach to these illnesses, considering the "single airway" concept and seeking treatment options that act on both asthma and rhinitis when the two conditions present simultaneously.

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“…(12,21) The prevalence of wheezing is generally higher in males in the first decade of life-when the caliber of their airways is smaller than is that of the females-and the opposite is observed from puberty onward. (22) Studies have also indicated the influence of the female sex hormones in the expression of asthma, and some of that epidemiological evidence has emerged from natural models, that is, menstrual cycles, pregnancy and menopause. (23)(24)(25) In addition, greater contact with the medical professional due to gynecological problems or prenatal care would increase the opportunity to report other conditions-including asthma and allergiesamong female adolescents, who are also subject to gender-specific environmental exposure, such as exposure to cosmetic products.…”

Section: Discussionmentioning

confidence: 99%

Prevalência de asma em adolescentes na cidade de Fortaleza, CE

Luna¹,

Almeida

Silva

2009

J. bras. pneumol.

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Objective: To determine the prevalence of asthma among adolescents (13-14 years of age) in the city of Fortaleza, Brazil. Methods: This was a cross-sectional study involving 3,015 adolescents at public and private schools between 2006 and 2007. The participants completed the International Study of Asthma and Allergies in Childhood questionnaire. Results: The prevalences of "wheezing ever", "wheezing within the last 12 months" (active asthma) and "asthma ever" (physician-diagnosed asthma) were 44.1%, 22.6% and 11.6%, respectively. The prevalences of "wheezing ever" (p = 0.001), "1-3 wheezing attacks within the last 12 months" (p = 0.001), active asthma (p = 0.002), "sleep disturbed due to wheezing less than one night per week" (p < 0.001) and "dry cough at night" (p < 0.001) were higher among girls. Private school students presented higher prevalences of "wheezing ever", active asthma, "1-3 wheezing attacks within the last 12 months", "4-12 wheezing attacks within the last 12 months" and physician-diagnosed asthma (p < 0.001 for all), as well as of "exercise-induced wheezing" (p = 0.032). Conclusions: The prevalence of asthma and asthma-related symptoms in students aged 13-14 years in the city of Fortaleza, Brazil, was high, predominantly among girls and private school students. The difference between the prevalence of physician-diagnosed asthma and that of active asthma suggests that asthma was underdiagnosed in the population studied.Keywords: Asthma/diagnosis; Asthma/epidemiology; Asthma/prevalence. ResumoObjetivo: Avaliar a prevalência de asma em adolescentes (13-14 anos) na cidade de Fortaleza, CE. Métodos: Estudo transversal utilizando o questionário do International Study of Asthma and Allergies in Childhood e envolvendo 3.015 adolescentes de escolas públicas e privadas entre 2006 e 2007. Resultados: As prevalências de "sibilos alguma vez na vida", "sibilos nos últimos doze meses" (asma ativa) e "asma alguma vez na vida" (asma diagnosticada) foram, respectivamente, 44,1%, 22,6% e 11,6%. As prevalências de "sibilos alguma vez na vida" (p = 0,001), "1-3 crises de sibilos nos últimos 12 meses" (p = 0,001); asma ativa (p = 0,002); "sono interrompido por sibilos menos que uma vez por semana" (p < 0,001) e "tosse seca noturna" (p < 0,001) foram maiores nas adolescentes. Alunos de escolas privadas apresentaram maior prevalência de "sibilos alguma vez na vida", asma ativa, "1-3 crises de sibilos nos últimos 12 meses", "4-12 crises de sibilos nos últimos 12 meses" e asma diagnosticada (p < 0,001 para todos), além de "sibilos após exercícios" (p = 0,032). Conclusões: A prevalência de asma e de sintomas associados em escolares de 13-14 anos na cidade de Fortaleza mostrou-se elevada, predominando no sexo feminino e no grupo das escolas privadas. A diferença entre as prevalências de asma diagnosticada e a de asma ativa sugere que a asma foi subdiagnosticada na população estudada.Descritores: Asma/diagnóstico; Asma/epidemiologia; Asma/prevalência. to the development of those diseases. The third phase was designe...

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It's all about sex: gender, lung development and lung disease

Cited by 352 publications

References 69 publications

Do Birth Season and Sex Affect Adult Lung Function as Early Life Factors?

Do Birth Season and Sex Affect Adult Lung Function as Early Life Factors?

Prevalência e associação de asma e rinite em adolescentes de 13 e 14 anos de Fortaleza, Ceará, Brasil

Prevalência de asma em adolescentes na cidade de Fortaleza, CE

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