It’s either a cook or a baker: Patients with conduction aphasia get the gist but lose the trace

Baldo, Juliana V.; Klostermann, Ellen C.; Dronkers, Nina F.

doi:10.1016/j.bandl.2007.12.007

Cited by 75 publications

(68 citation statements)

References 31 publications

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“…Left-frontal-left-posterior functional connectivity, also in concert with left-frontal-right-posterior functional connectivity, has previously been reported by fMRI studies on verbal working memory (Ma et al, 2011;Woodward et al, 2006). Structurally, leftfrontal-left-posterior theta coherence could relate to the underlying white matter of the left arcuate and superior-longitudinal fasciculi, whose relevance has been suggested for verbal working memory (Baldo, Klostermann, & Dronkers, 2008;Meyer, Cunitz, Obleser, & Friederici, 2014;Yamada et al, 2007) and sentence comprehension under increased verbalworking-memory demands (Friederici, 2011;Friedmann & Gvion, 2003;Meyer et al, 2014; M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 21 Meyer, Obleser, Anwander, et al, 2012;Wilson et al, 2011). Conceptually, theta oscillations might be supposed to mediate the sequential activation of words' long-term-memory representations into a cumulative sentence-level verbal-working-memory representation (Bastiaansen & Hagoort, 2006;Bastiaansen et al, 2010;Bastiaansen et al, 2008;Bastiaansen et al, 2005).…”

Section: A N U S C R I P Tmentioning

confidence: 87%

Frontal–posterior theta oscillations reflect memory retrieval during sentence comprehension

Meyer

Grigutsch

Schmuck

et al. 2015

Cortex

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Section: A N U S C R I P Tmentioning

confidence: 87%

Frontal–posterior theta oscillations reflect memory retrieval during sentence comprehension

Meyer

Grigutsch

Schmuck

et al. 2015

Cortex

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“…The role of the ADS in speech production is also demonstrated via a series of studies that directly stimulated sub-cortical fibers during surgical operations (Duffau, 2008-review), and reported that interference in the left pSTG and IPL resulted in an increase in speech production errors, and interference in the left IFG resulted in speech arrest (see also Acheson et al, 2011;Stewart et al, 2001 for similar results using magnetic interference in healthy individuals). Damage to Spt-IPL was also correlated with impaired ability to repeat sentences and unfamiliar words (conduction aphasia; Selnes et al, 1985;Axer et al, 2001;Bartha and Benke, 2003;Dronkers et al, 2004;Baldo et al, 2008Baldo et al, , 2012Fridriksson et al, 2010;Buchsbaum et al, 2011). One study even reported that stimulation of the left IPL resulted with patients believing that they spoke, when they didn't, and IFG stimulation resulted with the patients unconsciously moving their lips (Desmurget et al, 2009).…”

Section: The Ads and The Emergence Of Speechmentioning

confidence: 99%

From where to what: A neuroanatomically based evolutionary model of the emergence of speech in humans

Poliva

2018

Proceedings of the 12th International Conference on the Evolution of Language (Evolang12)

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In the brain of primates, the auditory cortex connects with the frontal lobe via the temporal pole (auditory ventral stream; AVS) and via the inferior parietal lobe (auditory dorsal stream; ADS). The AVS is responsible for sound recognition, and the ADS for sound-localization, voice detection and integration of calls with faces. I propose that the primary role of the ADS in non-human primates is the detection and response to contact calls. These calls are exchanged between tribe members (e.g., mother-offspring) and are used for monitoring location. Detection of contact calls occurs by the ADS identifying a voice, localizing it, and verifying that the corresponding face is out of sight. Once a contact call is detected, the primate produces a contact call in return via descending connections from the frontal lobe to brainstem motor nuclei. Because the ADS of present day humans also performs speech production and repetition, I further propose an evolutionary course for the transition from contact call exchange to an early form of speech. In accordance with this model, structural changes to the ADS endowed early members of the genus Homo with partial vocal control. This development was beneficial as it enabled offspring to modify their contact calls with intonations for signaling high or low levels of distress to their mother. Eventually, individuals were capable of participating in yes-no question-answer conversations. In these conversations the offspring emitted a low-level distress call for inquiring about the safety of objects (e.g., food), and the mother responded with a high-or low-level distress call to signal approval or disapproval of the interaction. Gradually, the ADS and its connections with brainstem motor regions became more robust and vocal control became more volitional. Speech emerged once vocal control was sufficient for inventing novel calls.

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“…The most severely affected cases frequently forgot the entire sentence immediately. Although the errors typically allowed patients to retain the semantic gist, 32 occasionally the meaning was altered. For example, for the target sentence, "The girl who lives upstairs in my block of flats is in my class," the response of Case 1 (see Fig 3) was, "The girl that lives in the block of flats upstairs is in the same school as me" (scoring 0 of 3).…”

Section: Language Profilementioning

confidence: 99%

Developmental conduction aphasia after neonatal stroke

Northam

Adler

Eschmann

et al. 2018

Annals of Neurology

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Objective: Impairment of speech repetition following injury to the dorsal language stream is a feature of conduction aphasia, a well-described "disconnection syndrome" in adults. The impact of similar lesions sustained in infancy has not been established. Methods: We compared language outcomes in term-born individuals with confirmed neonatal stroke (n 5 30, age 5 7-18 years, left-sided lesions in 21 cases) to matched controls (n 5 40). Injury to the dorsal and/or ventral language streams was assessed using T 1 -and T 2 -weighted magnetic resonance imaging (MRI) and diffusion tractography. Language lateralization was determined using functional MRI. Results: At the group level, left dorsal language stream injury was associated with selective speech repetition impairment for nonwords (p 5 0.021) and sentences (p < 0.0001). The majority of children with significant repetition impairment had retained left hemisphere language representation, but right hemisphere dominance was correlated with minimal or absent repetition deficits. Post hoc analysis of the repetition-impaired group revealed additional language-associated deficits, but these were more subtle and variable. Interpretation: We conclude that (1) despite the considerable plasticity of the infant brain, early dorsal language stream injury can result in specific and long-lasting problems with speech repetition that are similar to the syndrome of conduction aphasia seen in adults; and (2) language reorganization to the contralateral hemisphere has a protective effect.

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It’s either a cook or a baker: Patients with conduction aphasia get the gist but lose the trace

Cited by 75 publications

References 31 publications

Frontal–posterior theta oscillations reflect memory retrieval during sentence comprehension

Frontal–posterior theta oscillations reflect memory retrieval during sentence comprehension

From where to what: A neuroanatomically based evolutionary model of the emergence of speech in humans

Developmental conduction aphasia after neonatal stroke

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