2017
DOI: 10.1016/j.ejpb.2016.12.004
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It takes more than a coating to get nanoparticles through the intestinal barrier in vitro

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Cited by 32 publications
(17 citation statements)
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“…Our data on cellular silver uptake show that only a minor proportion of silver is taken up by the cells. This is in line with previous findings, for example with results obtained in Caco‐2 intestinal cells, which show that an uptake of silver nanoparticles into these cells occurs, but only to a minor degree (Lichtenstein et al, ). Even if only a limited number of time points have been investigated in the course of this proteomics‐centered study, the present results on silver uptake may help to elucidate some aspects of the kinetics of silver uptake in Hep G2 cells.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Our data on cellular silver uptake show that only a minor proportion of silver is taken up by the cells. This is in line with previous findings, for example with results obtained in Caco‐2 intestinal cells, which show that an uptake of silver nanoparticles into these cells occurs, but only to a minor degree (Lichtenstein et al, ). Even if only a limited number of time points have been investigated in the course of this proteomics‐centered study, the present results on silver uptake may help to elucidate some aspects of the kinetics of silver uptake in Hep G2 cells.…”
Section: Discussionsupporting
confidence: 93%
“…Silver nanoparticles continuously release silver ions (Juling et al, ; Lichtenstein et al, ) and it is generally accepted that the released ions are responsible for the main toxicological consequences of exposure to silver nanoparticles (Gaillet & Rouanet, ; Kim & Ryu, ; McShan, Ray, & Yu, ). However, (nano)particle‐specific cellular uptake and/or related molecular effects cannot be ruled out at the present state of research.…”
Section: Introductionmentioning
confidence: 99%
“…Although mucosae are an efficient barrier against many external antigens, NPs are designed to traverse this layer to effectively carry out their function of delivering small molecules into the bloodstream and various other tissues throughout the body . Images from transmission electron microscopy show that certain NPs, such as TiO 2 , ZnO, SiO 2 , Fe 3 O 4 , and Ag, accumulate at the cell surface, within the cytoplasm, and within subcellular structures of IECs, M cells, Peyer's patches, and associated macrophages within the gastrointestinal tract, as well as various cell lines in vitro . Complete translocation of TiO 2 NPs through the epithelial barrier has also been demonstrated in vitro in a follicle‐associated epithelium (FAE) model, but not in an IEC monolayer model, indicating the primary route across the intestinal barrier for TiO 2 NPs is likely to occur through M cells via endocytosis .…”
Section: Nps and The Intestinal Barriermentioning
confidence: 99%
“…From a risk assessment perspective, understanding the fate, cellular interactions (i.e. cellular uptake) and bioavailability of AgNPs upon digestion is of key importance to assess their impact on health (Bouwmeester et al 2011;Hsiao et al 2016;Lichtenstein et al 2015Lichtenstein et al , 2017 Upon oral ingestion of AgNPs, these particles pass through several compartments of the gastrointestinal tract (mouth, stomach and intestine), each with a specific pH and biochemical composition. These varying conditions can affect the AgNPs physicochemical properties (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…These varying conditions can affect the AgNPs physicochemical properties (e.g. agglomeration and dissolution) and accordingly affect their bioavailability and toxicological properties (B€ ohmert et al 2014;Lichtenstein et al 2017;Murdock et al 2008;Sieg et al 2017). Upon reaching the intestine, the biological interactions (e.g.…”
Section: Introductionmentioning
confidence: 99%